伊维菌素微球在山羊体内的药效学研究  

Pharmacodynamics Study of Ivermectin Microspheres in Goats

作　　者：肖田安 许颖[2] 李帅鹏[2] 陈杖榴[2] 黄显会[2] 

机构地区：[1]广东省兽药饲料质量检验所,广东广州510230 [2]华南农业大学兽医学院,广东广州510642

出　　处：《中国兽医杂志》2014年第3期66-68,共3页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金面上项目(39770572)

摘　　要：探讨新型制剂伊维菌素微球在山羊体内的药效学.选取32只山羊[平均体重（27.05± 1.20） kg],随机分成4组（Ⅰ～Ⅳ）,每组7～9只.Ⅰ组0.3 mg/kg体重,皮下注射伊维菌素注射液;Ⅱ和Ⅲ组3mg/kg体重,分别皮下注射伊维菌素PLA5微球和PLGA微球混悬液;Ⅳ组作为对照组,不给药,对山羊粪便虫卵数（EPG）进行检测.Ⅰ、Ⅱ组和Ⅲ组山羊在第14天虫卵减少率均为100％,虫卵全部转阴;在给药后91 d虫卵减少率分别为0、74.3％和80.0％、;在给药后123 d分别为0、61.8％和0.伊维菌素对山羊胃肠道线虫虫卵具有较好的驱除作用,PLGA微球和PLA5微球的药效维持长达120 d左右,表现出长效作用.The present study was aimed to evaluate the efficacy of new preparations ivennectin mierospheres in goats. 32 goats （average weight 27.05±1.20 kg）were selected and randomly divided into four groups（Groups Ⅰ-Ⅳ）. Groups Ⅰ was administered Ivermectin Injection subcutaneously at a dose of 0.3 mg/kg body weight, groups Ⅱ and IB were administered Ivermectin PLA5 microspheres and PLGA microspheres subcutaneously at a dose of 3 mg/kg respectively. GroupslV was set as the control group, and was not given any drugs. Through the EPG（eggs per gramme） test, the amount of eggs found in the decrement of groups Ⅰ ,Ⅱ and m were 100% 14 days after administration ,and 0,74.3% and 80.0% respectively in 90 days after administration ,0%.61.8% and 0% respectively in 123 days after administration. The persistent efficacy of PLA5 microspheres and PLGA microspheres lasted for 120 days. Ivermectin has a good reductive effect on goat gastrointestinal nematodes eggs, PLGA microspheres and PLA5 microspheres showed long-lasting effects （about 120 days）.

关 键 词：伊维菌素 微球 药效学 山羊 

分 类 号：S859.796[农业科学—临床兽医学]