Construction of Photoresponsive Supramolecular Micelles Based on Ethyl Cellulose Graft Copolymer  

作　　者：Chun-mei Jian Bo-wen Liu Xi Chen Si-tong Zhou Tommy Fang 袁金颖 

机构地区：[1]Key Lab of Organic Optoelectronic & Molecular Engineering of Ministry of Education, Department of Chemistry,Tsinghua University

出　　处：《Chinese Journal of Polymer Science》2014年第6期690-702,共13页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.21174076 and 21374053);the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20120002110015)

摘　　要：In this work, a UV-Visible light controlled supramolecular system based on ethyl cellulose （EC） was constructed, combining the host-guest interaction of β-cyclodextrin （β-CD） group and trans-isomer of azobenzene （tAzo） group. To link β-CD to the hydrophobic section, renewable EC was used as macroinitiator to initiate the polymerization of ε-caprolactone （ε-CL） to form biocompatible and biodegradable comb copolymer EC-g-PCL, and β-CD was attached to the end of PCL side chain via click reaction. Meanwhile, hydrophilic PEG-tAzo was obtained by N,N＇-dicyclohexylcarbodiimide （DCC） coupling. Then, the structures of the products were characterized by nuclear magnetic resonance （NMR） and gel permeation chromatography （GPC）. Subsequently, with the formation of inclusion complexes by β-CD and tAzo groups, the obtained EC-g-PCL-β-CD/PEG-tAzo supramolecular system self-assembled in water with hydrophobic EC-g-PCL-β-CD as core and hydrophilic PEG-tAzo as shell. Furthermore, dynamic light scattering （DLS） and transmission electron microscopy （TEM） were utilized to investigate the particle size and size distribution, while NMR and UV-Vis spectra were applied to explore the UV-Visible light stimuli-responsiveness of the micelles.In this work, a UV-Visible light controlled supramolecular system based on ethyl cellulose （EC） was constructed, combining the host-guest interaction of β-cyclodextrin （β-CD） group and trans-isomer of azobenzene （tAzo） group. To link β-CD to the hydrophobic section, renewable EC was used as macroinitiator to initiate the polymerization of ε-caprolactone （ε-CL） to form biocompatible and biodegradable comb copolymer EC-g-PCL, and β-CD was attached to the end of PCL side chain via click reaction. Meanwhile, hydrophilic PEG-tAzo was obtained by N,N＇-dicyclohexylcarbodiimide （DCC） coupling. Then, the structures of the products were characterized by nuclear magnetic resonance （NMR） and gel permeation chromatography （GPC）. Subsequently, with the formation of inclusion complexes by β-CD and tAzo groups, the obtained EC-g-PCL-β-CD/PEG-tAzo supramolecular system self-assembled in water with hydrophobic EC-g-PCL-β-CD as core and hydrophilic PEG-tAzo as shell. Furthermore, dynamic light scattering （DLS） and transmission electron microscopy （TEM） were utilized to investigate the particle size and size distribution, while NMR and UV-Vis spectra were applied to explore the UV-Visible light stimuli-responsiveness of the micelles.

关 键 词：Ethyl cellulose Supramolecular system SELF-ASSEMBLY Photoresponse. 

分 类 号：O636.11[理学—高分子化学]