吸收促进剂对芍药苷大鼠肠道吸收的促进作用研究  

Promotion of enhancers on duodenal absorption of paeoniflorin in rats

作　　者：易军[1] 吴秋平[1] 张凤玲[1] 黄燕芬[1] 

机构地区：[1]广东药学院药科学院,广东广州510006

出　　处：《药物评价研究》2014年第2期141-144,共4页Drug Evaluation Research

基　　金：广东省科技计划项目(2011B031700060);广东药学院大学生创新训练项目(1057313015)

摘　　要：目的考察不同吸收促进剂对芍药苷在大鼠十二指肠吸收过程的影响,筛选最佳吸收促进剂。方法利用大鼠在体单向肠灌流模型,采用HPLC法测定灌流液中芍药苷含量,分别考察聚山梨酯80、羟丙基-β-环糊精、癸酸钠、去氧胆酸钠和当归提取物对吸收的促进作用。结果羟丙基-β-环糊精和当归提取物能显著提高芍药苷的肠道吸收速率,其次是癸酸钠和聚山梨酯80,而去氧胆酸钠则没有作用。结论羟丙基-β-环糊精和当归提取物可作为芍药苷口服制剂的吸收促进剂使用,中药当归配伍芍药使用是合理、有效的。Objective To investigate the effects of different enhancers on the transport properties of paeoniflorin in rat duodenum, in order to select the best absorption enhancers. Methods In situ single-pass intestinal perfusion model was performed to study the absorption ofpaeoniflorin. The concentration ofpaeoniflorin was determined by HPLC. Tween 80, HP-β-CD, sodium caprate, sodium deoxycholate, and angelica extract were chosen as the enhancers. Results HP-β-CD and angelica extract significantly improved the rate of duodenal absorption of paeoniflorin, followed by sodium caprate and Tween 80, and sodium deoxycholate had no effect. Conclusion HP-β-CD and angelica extract would be used as enhancers in oral paeoniflorin formulations. Angelica and peony pairs are reasonable and effective.

关 键 词：芍药苷 吸收促进剂 大鼠在体单向肠灌流 当归 

分 类 号：R286.0[医药卫生—中药学]