鼻腔-鼻窦恶性肿瘤组织bFGF与TSP-1表达及意义  

EXPRESSIONS OF BFGF AND TSP-1IN MALIGNANT TUMORS OF NASAL AND PARANASAL CAVITY

作　　者：胡晓璇[1] 孙洁[2] 薛卫国[2] 刘勤松[2] 

机构地区：[1]潍坊医学院,山东潍坊261000 [2]青岛市市立医院耳鼻喉科

出　　处：《齐鲁医学杂志》2014年第2期105-106,108,共3页Medical Journal of Qilu

摘　　要：目的 探讨碱性成纤维细胞生长因子（bFGF）及血小板反应蛋白-1（TSP-1）与鼻腔-鼻窦恶性肿瘤生成的关系及临床意义。方法 采用免疫组化Supervision法对54例鼻腔-鼻窦恶性肿瘤、43例良性肿瘤及30例鼻息肉组织中bFGF及TSP-1的表达进行检测。结果 bFGF和TSP-1在鼻腔-鼻窦恶性肿瘤、良性肿瘤及鼻息肉中的阳性表达差异有显著性（χ2=5.06～32.43，P〈0.05）。结论 bFGF可能对鼻腔-鼻窦恶性肿瘤的生成具有促进作用，而TSP-1可能具有抑制其生成的作用。Objective To investigate the association of basic fibroblast growth factor （bFGF） and Thrombospondin-1 （TSP-1） with the oncogenesis of malignant tumors in nasal cavity and paranasal. Methods The expressions of bFGF and TSP- 1 proteins were detected by immunohistochemical staining in 54 cases of malignant tumors in nasal cavity and paranasal sinus,43 cases of benign tumors, and 30 cases of nasal polyps. Results The differences of the expressions of bFGF and TSP-1 among malignant tumors, benign tumors and polyps in nasal and paranasal were statistically significant （X2 =5.06-32.43,P〈0.05）. Conclusion bFGF is likely to promote the development of nasal and paranasal malignant tumors, and TSP-1 is probably to inhibit the occurrence of the malignancies.

关 键 词：鼻窦肿瘤 成纤维细胞生长因子 血小板反应蛋白-1 免疫组织化学 

分 类 号：R765.2[医药卫生—耳鼻咽喉科]