自乳化释药系统(SEDDS)对姜黄素类组分增溶作用的研究  

Solubilization of self-emulsifying drug delivery system(SEDDS) for curcumin components

作　　者：柯秀梅[1,2] 杨荣平[1,2] 郭响香 周文杰[1,2] 陈小川[2] 梁旭明[2] 王云红[2] 

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]重庆市中药研究院重庆市中药资源重点实验室,重庆400065 [3]陕西中医学院,陕西咸阳712000

出　　处：《中草药》2014年第7期935-941,共7页Chinese Traditional and Herbal Drugs

基　　金：重庆市GLP中心能力提升建设(cstc2012pt-kyys10001);重庆自然科学基金课题(cstc2012jjA1415);中药新产品开发研究能力提升建设(cstc2012pt-kyys10004)

摘　　要：目的探讨自乳化释药系统(SEDDS)对多组分同时增溶的可行性。方法以姜黄素类组分为模型药物,采用D-最优混料设计优化SEDDS处方,以对双去甲氧基姜黄素、去甲氧基姜黄素和姜黄素的载药量、SEDDS的粒径和乳化时间为指标对SEDDS进行优化并对其进行综合评价,探讨SEDDS对多成分同时增溶的可行性。结果优化得SEDDS最佳处方为Obleique CC497-聚山梨酯20-Transcutol P(0.21∶0.50∶0.29),SEDDS粒径为(248.8±3.4)nm,乳化时间为(70±1)s。37℃时,SEDDS对双去甲氧基姜黄素、去甲氧基姜黄素和姜黄素的最大载药量分别为2.298、12.220、52.561 mg/g,在水中的溶解度分别为0.107、0.661、1.648 mg/mL。结论SEDDS能实现对多组分的同时增溶。Objective To explore the feasibility of self-emulsifying drug delivery system （SEDDS） for multicomponents simultaneous solubilization. Methods The curcumin （Cur） components were used as model drug, D-optimal mixture design was used to optimize SEDDS prescription, and the contents of bisdemethoxycurcumin （BDMC）, demethoxycurcumin （DMC）, and Cur, SEDDS particle size, and emulsifying time were made as indicators to select and evaluate SEDDS, so as to explore the feasibility of SEDDS for the multicomponents simultaneous solubilization. Results The optimal SEDDS prescription was Obleique CC497-Tween 20-Transcutol P （0.21 ： 0.50 ： 0.29）, SEDDS particle size was （248.8 ± 3.4） run, and emulsifying time was （70 ±1） s. At 37 ℃; the maximum loading capacities of SEDDS for BDMC, DMC, and Cur were 2.998, 12.220, and 52.561 rag/g, respectively, and the solubilities in water were 0.107, 0.661, and 1.648 mg/mL. Conclusion SEDDS can realize the solubilization of multicomponent simultaneously.

关 键 词：自乳化释药系统 增溶 姜黄素 双去甲氧基姜黄素 去甲氧基姜黄素 D-最优混料设计 

分 类 号：R283.6[医药卫生—中药学]