五环三萜类化合物抗HIV研究进展  

Advances on Pentacyclic triterpenoids in anti-HIV

作　　者：张丽[1,2] 李群林[1] 李灵芝[1,2] 

机构地区：[1]武警后勤学院药物化学教研室,天津300309 [2]天津市职业与环境危害防制重点实验室,天津300309

出　　处：《武警后勤学院学报（医学版）》2014年第3期263-268,共6页Journal of Logistics University of PAP（Medical Sciences）

基　　金：国家自然科学基金(81073152);天津市科技攻关项目(12JCZDJC34700);武警医学院面上项目(WYM201014)

摘　　要：为克服现有艾滋病治疗药物毒性大及易产生耐药性的缺点,近年来,不少学者以天然化合物为先导物进行结构改造,以期发现活性高、毒性小的新型抗艾滋病药物,其中,对五环三萜类化合物白桦酸、齐墩果酸、熊果酸C-3位羟基、C-28位羧基、以及C12-13位双键等基团进行结构改造的研究取得了一定进展,对治疗AIDS显示了巨大潜力。For overcoming the toxicity and drug resistance in existing drug for theating of AIDS, the structure modifications of nature occurring component as the leading compound have been carried out by researchers, for getting high activity and low toxicity anti-AIDS drug in recent years. And in these components, some development have been achieved on the pentacyclic triterpenoids, such as reorganizating to C-3 hydroxyl, C-28 carboxyl Group and C12-13 double bond of betulinic acid and oleanolic acid and ursolic acid, which shows great potential in AIDS therapy.

关 键 词：人免疫缺陷病毒 五环三萜 白桦酸 齐墩果酸 

分 类 号：R917[医药卫生—药物分析学]