急性胆道系统感染围手术期降钙素原指导下抗生素应用的临床价值  

The clinical value of prophylactic antibiotic application under the guidance of procalcitonion in perioperative period of acute biliary system infection

作　　者：李绍堂[1] 郑晓风[1] 蔡华杰[1] 朱恒梁[1] 阮小蛟[1] 蒋飞照[1] 

机构地区：[1]温州医科大学附属第一医院普外科,浙江温州325000

出　　处：《肝胆胰外科杂志》2014年第2期102-104,共3页Journal of Hepatopancreatobiliary Surgery

基　　金：温州市科技局资助项目(Y20130095)

摘　　要：目的探讨急性胆道感染围手术期降钙素原指导下抗生素应用的临床价值。方法观察与分析120例拟行手术治疗的急性胆道感染患者围手术期抗生素应用情况,其中60例患者(试验组)在入院后第1、3、5天的隔日抽血化验降钙素原及血常规水平,至研究截点。在降钙素原正常(<0.5 ng/mL)时,停用抗生素;其余60例患者依据传统标准停用抗生素。比较两组患者治愈时间、感染相关并发症与抗生素应用天数。结果两组患者治愈时间和感染并发症发生率无统计学差异(P>0.05)。两组患者平均用药时间比较,试验组明显低于对照组(P<0.001)。结论急性胆道感染围手术期降钙素原指导下抗生素应用要优于传统标准抗生素应用。Objective To observe the clinical value of antibiotic application under the guidance of procalcitonionin perioperative period of acute biliary system infection. Methods Antibiotic application in 120 cases of acute biliary system infection in perioperative period were analyzed. Sixty patients （experimental group） were tested for procalcitonion and blood routine on 1 st, 3rd, 5th day after admission. Antibiotics was stopped using under the normal level of procalcitonion （〈0.5 ng/mL）. The rest of 60 patients （control group） were stopped using antibiotics on the basis of traditional standard. Results There was no significant difference between two groups in cure time and infection complications （P〉0.05）; there was very significant difference between two groups in average dura- tion of antibiotic application, the experimental group was significantly shorter than the control group （P〈0.001）. Conelusion Antibiotic application under the guidance of procalcitonion is superior to the traditional standard in perioperative period of acute biliary system infection.

关 键 词：降钙素原 急性胆道感染 围手术期 抗生素应用 

分 类 号：R657.4[医药卫生—外科学]