小剂量红霉素治疗支气管扩张稳定期的疗效观察  

Efficacy observation of lowe-dose erythromycin in the treatment of patients with bronchiectasis

作　　者：丁啸[1] 李宏云[1] 杨闪闪[1] 

机构地区：[1]郑州大学第五附属医院呼吸内科,450052

出　　处：《中国实用医刊》2014年第10期32-33,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察长期口服小剂量红霉素对支气管扩张症稳定期的临床疗效。方法38例门诊或住院治疗确诊为支气管扩张症的患者，在急性发作期积极治疗，病情稳定出院后随机分为实验组和对照组，每组22例。实验组给予口服氨溴索30mg，，每日3次，红霉素0．125mg，每日3次，疗程6个月。对照组仅给予口服氨溴索30mg，每日3次，疗程6个月。结果治疗期间，治疗组人均急性加重（0．85±0．08）次，较对照组人均急性加重次数[（1．78±0．06）次]明显减少（P〈0．05）。治疗10周后，治疗组人均痰量为（29．50±6．49）ml/d，较对照组人均痰量[（55．59±11．24）ml/d]明显减少（P〈0．05）。结论长期口服小剂量红霉素可减少支气管扩张稳定期的急性发作次数，改善临床症状，减少痰量。Objective To observe the clinical curative effect of long-term low-dose oral nerythro myci on the patients with bronchiectasis at stationary phase. Methods Thirty-eight outpatients or inpa tients that were diagnosed as bronehieetasis, were given active treatment at the acute episodes. And after they were in a stable condition and discharged, they were randomly divided into experimental group and control group, with 22 patients in each group. Patients in experimental group were given oral ammonia bromine （30 rag, 3 times per day） and erythromycin （0. 125 rag, 3 times per day）, the course was 6 months. And patients in control group were only given oral ammonia bromine （30 rag, 3 times per day） , the course was 6 months. Results During the treatment, the number of acute exacerbations per capita was （0. 85±0. 08 ） times in the treatment group, which was significantly reduced when compared to that of the control group[ （1.78 ± 0. 06） times I （P 〈 0. 05 ）. Ten weeks after the treatment, sputum volume per capita in the treatment group was （29.50 ± 6.49） ml/d, which was significantly reduced when com- pared to that of the control group [ （55.59 ± 11.24） ml/d ] （ P 〈 0. 05 ）. Conclusions Long-term low dose oral erythromycin can reduce the number of acute exacerbations of bronchiectasis at stationary phase, thus improve the clinical symptoms and decrease sputum volume.

关 键 词：支气管扩张 红霉素 急性加重 

分 类 号：R562.22[医药卫生—呼吸系统]