人类Ago2蛋白与肿瘤的关系研究  

Study on Relationship of Human Ago2 Protein and Tumors

作　　者：林爱琴[1] 赵跃华[1] 

机构地区：[1]皖南医学院基础医学院医学生物学教研室,安徽芜湖241001

出　　处：《安徽农业科学》2014年第11期3169-3171,3239,共4页Journal of Anhui Agricultural Sciences

摘　　要：Argonaute2(Ago2)蛋白是RNA诱导沉默复合体(RNA-induced silencing complex、RISC)的核心元件,不仅在miRNA/siRNA通路中促使靶mRNA降解或抑制其蛋白质翻译,调节miRNAs生物合成和成熟,对生物生长发育、干细胞分化和肿瘤形成等有密切关系。Argonaute2 （Ago2） protein,the core of RNA-induced silencing complex （RISC）,complexed with the guide strand of a small interfering RNA（siRNA） or a microRNA（miRNA） and ubiquitously expressed and binded to siRNAs or miRNAs to guide post-trascriptional gene silencing either by destabilization of the mRNA or by translational repression.It has important functions in processes as diverse as embryonic development,cell differentiation and tumor biogenesis.

关 键 词：Argonaute2 RISC 翻译抑制 肿瘤 

分 类 号：S188[农业科学—农业基础科学]