全身机械振动对去势骨质疏松大鼠血流变异常状态的干预作用  

Effect of general mechanical vibration on abnormal hemorheology status in ovariectomized osteoporotic rats

作　　者：谭新[1] 魏秋实[2] 陈现红[1] 孙伟珊[1] 邵玉[1] 邓伟民[1] 

机构地区：[1]广州军区广州总医院康复科,广州510010 [2]广州军区广州总医院博士后科研工作站,广州510010

出　　处：《中国骨质疏松杂志》2014年第4期353-356,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81273778);广东省科技计划省国际合作项目(2012B050600026)

摘　　要：目的探讨全身机械振动对去势骨质疏松大鼠血液流变学指标的影响。方法 24只7月龄SD雌性大鼠随机分成对照组、模型组、全身振动组、福美加组。治疗8周后,收集左侧股骨和全血分别行骨矿含量、骨密度和血液流变学检测。结果模型组的骨矿含量和骨密度低于对照组(P<0.05),对照组与福美加组骨密度高于模型组和全身振动组(P<0.05),而全身振动组高于模型组(P<0.05)。模型组200/S、30/S、3/S、TK、IR、EPT高于对照组(P<0.05),全身振动组30/S低于模型组(P<0.05),与对照组比较无统计学差异。结论去势大鼠存在血流变异常反应,全身机械振动可改善全血中切粘度30/S异常状态,提高骨矿含量和骨密度。Objective To investigate the effect of general mechanical vibration on hemorheology in ovariectomized osteoporotic rats. Methods Twenty-four 7-month female SD rats were randomly divided into 4 groups ： control group, ovariectomized group, general mechanical vibration group, and Fumeijia group. After 8-week treatment, the bone mineral density （BMD） and the bone mineral content （BMC） of the left femur was detected. Hemorheology detection was also performed. Results BMC and BMD in ovariectomized group were significantly lower than those in control group （ P 〈 0. 05 ）. BMD in control group and Fumeijia group was significantly higher than that in ovariectomized group and general mechanical vibration group （ P 〈 0.05 ）. BMD in general mechanical vibration group was higher than that in ovariectomized group （ P 〈 0.05 ）. Compared with that in control group, the levels of 200/S, 30/S, 3/S, TK, IR, and EPT in ovariectomized group increased significantly （ P 〈 0. 05）. The level of 30/s in general mechanical vibration group was lower than that in ovariectomized group （P 〈 0.05 ）. Compared with that in control group, no significant difference was observed. Conclusion The hemorheology in ovariectomized rats is abnormal. The general mechanical vibration can improve the abnormal viscosity of 30/s in whole blood, and increase BMD and BMC in variectomized rats.

关 键 词：全身机械振动 去势大鼠 骨质疏松 血液流变 

分 类 号：R332[医药卫生—人体生理学]