女性护骨素和转化生长因子-β水平对骨转换率的影响  

Effect of osteoprotegerin and transforming growth factor-β on bone turnover rate in women

作　　者：钟如意[1] 伍西羽[2] 陈胜[1] 李妙[1] 伍贤平[2] 廖二元[2] 

机构地区：[1]湖南省浏阳市人民医院内分泌科,湖南浏阳410300 [2]中南大学代谢内分泌研究所,湘雅二医院内分泌科,长沙410011

出　　处：《中国骨质疏松杂志》2014年第4期387-391,共5页Chinese Journal of Osteoporosis

摘　　要：目的了解女性护骨素(OPG)和转化生长因子-β(TGF-β)与骨转换指标的关系及其对骨转换指标的影响。方法研究长沙地区691名健康女性(年龄20~80岁)的血清OPG、TGF-β1和TGF-β2,以及血清骨特异性碱性磷酸酶(BAP)、骨钙素(OC)、血清I型胶原N-末端肽(sNTX)、血清I型胶原C-末端肽(sCTX)、尿NTX(uNTX)、尿CTX(uCTX)和尿脱氧吡啶酚(uDPD),并分析这些细胞因子与各种骨转换指标之间的关系。结果血清OPG和TGF-β2与血清BAP、OC、uNTX、uCTX和uDPD呈显著正相关(r=0.145~0.397,P均=0.000),血清TGF-β1与BAP、OC、sCTX、uNTX和uCTX呈显著负相关(r=-0.114^-0.286,P均=0.004~0.000)。调整年龄和BMI之后,它们之间的偏相关系数多数仍然有意义。多元线性回归分析显示,OPG和TGF-β2对BAP、uNTX和uCTX是一个正性决定因素,可分别解释这些指标0.6%~16.6%的变异。TGF-β1对BAP、OC、和uCTX是一个负性决定因素,可以分别解释这些指标变异的0.7%~7.3%。结论本研究揭示了女性OPG和TGF-β与骨转换指标的关系,提示循环中的OPG和TGF-β是骨转换速率的重要决定因素。Objective To explore the relationship among osteoprotegerin （OPG）, transforming growth factor-β （TGF-β）, and bone turnover markers, and to investigate their effect on bone turnover markers. Methods Cross-sectional study was conducted in 691 healthy women in Changsha, aging from 20 to 80 years old. The serum levels of OPG, TGF-β1 , TGF-β2 , serum bone-specific alkaline phosphatase （BAP） , osteocalcin （OC）, serum cross-linked N-terminal telopeptides of type I collagen （sNTX） , and serum cross-linked C-terminal telopeptides of type I collagen （sCTX） were detected. Simultaneously, the levels of urinary cross-linked N- terminal telopeptides of type I collagen （ uNTX）, urinary cross-linked C-terminal telopeptides of type I collagen （ uCTX）, and urinary deoxypyridinoline （uDPD） were also detected. The relationship between these cytokines and the bone turnover markers was analyzed. Results The serum OPG and TGF-132 were significantly positively correlated with serum BAP, OC, uNTX, uCTX, and uDPD （r = 0. 145 -0. 397, all P =0. 000）. The serum TGF-β1was significantly negatively correlated with BAP, OC, sCTX, uNTX, and uCTX （ r = - 0. 114 - 0. 286, all P = 0. 004 - 0. 000）. After adjusting age and BMI, the significance of partial correlation coefficients also existed. Multivariate linear regression analysis indicated that OPG and TGF-132 were positive determinants to BAP, uNTX, and uCTX, explaining 0.6% - 16. 6% variance of these markers, respectively. TGF-β1 was a negative determinant to BAP, OC, and uCTX, explaining 0. 7% - 7.3% variance of these markers, respectively. Conclusion The relationship among OPG, TGF-β, and bone turnover markers in females are revealed in this study, indicating that OPG and TGF-β in circulation are important determinants to the bone turnover rate.

关 键 词：护骨素 转化生长因子-Β 骨转换指标 女性 

分 类 号：R816.8[医药卫生—放射医学]