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机构地区:[1]河南大学药学院,河南开封475001 [2]天津药物研究院释药技术与药代动力学国家重点实验室天津市新药设计与发现重点实验室,天津300193
出 处:《现代药物与临床》2014年第4期338-341,共4页Drugs & Clinic
摘 要:目的对比Parteck M200、M100直压甘露醇和直压甘露醇C、D 4种不同型号甘露醇对吲达帕胺直接压片的影响,为直接压片选择辅料提供参考。方法以吲达帕胺为模型药物考察粉体学,采用直压工艺与4种甘露醇压片后,进行片剂质量分析比较。结果 4种型号甘露醇对模型药物均有很好的容纳性,Parteck M200、M100直压甘露醇与吲达帕胺的相容性及混合压片后的溶出度较好。结论甘露醇是良好的直压工艺的填充剂,不同型号的甘露醇与模型药物混合有一定的差异。Objective To compare the effects of four different types ofmannitol, such as Parteck M200, M100, and mannitol C and D on indapamide for direct compression tableting and to provide the reference for the selection of production excipients for direct compression tableting. Methods The powder properties of four kinds of mannitol were compared. Using four kinds of mannitol to trial-produce Indapamide Tablets, the differences of the four kinds of mannitol were compared through analysis on the quality of tablets. Results All the four types of mannitol had a good containment on model drugs; Parteck~ M200 and M100 had a better compatibility of indapamide and a higher dissolution of its tablets. Conclusion Marmitol is a good filler for direct pressure process, and different types of mannitol have the certain influence on the content uniformity of model drugs.
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