单硝酸异山梨酯片联合定痛救心胶囊治疗冠脉介入术后再发稳定型心绞痛的临床疗效  

Clinical observation of Isosorbide Mononitrate Tablets combined with Dingtong Jiuxin Capsule used for treatment of stable angina pectoris reappeard after percutaneous coronary intervention

作　　者：孙媛[1] 

机构地区：[1]天津市中医药研究院附属医院心病科,天津300120

出　　处：《现代药物与临床》2014年第4期389-392,共4页Drugs & Clinic

基　　金：天津市卫生局科研基金资助课题(200019)

摘　　要：目的观察单硝酸异山梨酯片联合定痛救心胶囊对冠脉介入术(PCI)后再发稳定型心绞痛的临床疗效和安全性。方法将48例PCI后再发稳定型心绞痛患者随机分为治疗组(24例)和对照组(24例)。对照组口服单硝酸异山梨酯片20mg/次,3次/d;治疗组口服定痛救心胶囊6粒/次,3次/d,单硝酸异山梨酯片的用法和用量同对照组,两组患者均持续治疗8周。治疗结束后,观察两组患者临床疗效、心电图变化、中医证候疗效。结果治疗后治疗组临床疗效、心电图变化、中医证候疗效与对照组比较差异均有统计学意义(P<0.05)。结论单硝酸异山梨酯片联合定痛救心胶囊能有效地改善PCI术后再发稳定型心绞痛患者的疗效,且无不良反应,值得临床推广。Objective To investigate the clinical efficacy and safety oflsosorbide Mononitrate Tablets combined with Dingtong Jiuxin Capsule used for the treatment of stable angina pectoris reappeard after percutaneous coronary intervention. Methods The 48 cases of stable angina pectoris reappeard after percutaneous coronary intervention were randomly divided into treatment （24 cases） and control （24 cases） groups. The patients in the control group were po administered with Isosorbide Mononitrate Tablets 20 mg/time, three times daily. The patients in the treatment group werepo administered with Dingtong Jiuxin Capsule 6 pieces/time, three times daily, at the same time, Isosorbide Mononitrate Table at the usage and dosage was used as same in the control group. Two groups were treated for eight weeks. After the treatment, the changes of clinical curative effect, electrocardiogram, and traditional Chinese medicine （TCM） syndrome curative effect were observed in the two groups. Results The differences of clinical curative effect, electrocardiogram, and TCM syndrome curative effect between the two groups were statistically significant （P 〈 0.05）. Conclusion Isosorbide Mononitrate Tablets combined with Dingtong Jiuxin Capsule can effectively improve the curative effect of stable angina pectoris reappeard after percutaneous coronary intervention with no adverse reactions, which is worthy of the clinical promotion.

关 键 词：单硝酸异山梨酯片 定痛救心胶囊 稳定型心绞痛 冠脉介入术 

分 类 号：R972[医药卫生—药品]