响应面法优化氰霜唑合成工艺  

Optimization of Synthesis Process for Cyazofamid by Response Surface Methodolody

作　　者：张建功[1] 陈涛[1] 王列平[1] 苏天铎[1] 宁斌科[1] 

机构地区：[1]西安近代化学研究所,西安710065

出　　处：《农药》2014年第5期325-327,共3页Agrochemicals

摘　　要：[目的]以4-氯-2-氰基-5-(4'-甲基苯基)咪唑和N,N-二甲胺基磺酰氯为原料,合成氰霜唑,优化合成工艺。[方法]研究原料配比、反应时间和反应温度对产物产率的影响,并通过响应面法对合成工艺进行分析。[结果]得到了最优工艺条件:原料配比为1.13∶1,反应时间为4.6 h,反应温度为75℃,最终收率可达65.2%。[结论]研究为氰霜唑的工业化生产提供了最佳工艺条件。[Aims] Fungicide cyazofamid was synthesized with 4-chloro-2-cyano-5-（4＇-methyl phenyl） imidazole and N,N-dimethylsulfamoyl chloride as the raw materials to optimize the process. [Methods] The effects of raw material ratio, reaction time, reaction temperature on the reaction yield were researched. The reaction conditions were optimized by using the response surface method （RSM）. [Results] The optimal technological condition was obtained. The results showed that the highest yield can reach 65.2% when the raw material ratio is 1.13 ： 1, reaction time is 4.6 h, reaction temperature is 75 ℃. [Conclusions] This study provides the optimization condition of synthesis process for cyazofamid in industry.

关 键 词：氰霜唑 响应面法 咪唑 合成工艺 

分 类 号：TQ455.4[化学工程—农药化工]