运动疗法促进脑梗死患者下肢运动功能恢复与PDGF-BB的相关性研究  

Correlation research on exercise therapy and PDGF-BB to promote lower extremity motor function in patients with cerebrial infarction

作　　者：邹东华[1,2] 何世安[1] 雷斌[1] 陈昊[1] 严翼飞[1] 卢华文[1] 刘新丁[1] 陈莉[2] 

机构地区：[1]中国人民解放军第三0三医院,广西南宁530021 [2]广西医科大学第一附属医院神经内科,广西南宁530021

出　　处：《中风与神经疾病杂志》2014年第4期335-337,共3页Journal of Apoplexy and Nervous Diseases

基　　金：广西医药卫生科研项目(No.Z2012473);广西自然科学基金项目(No;2012GXNSFAA276028)

摘　　要：目的探讨运动疗法促进脑梗死患者下肢运动功能恢复与PDGF-BB的相关性。方法随机将73例脑梗死患者分为脑梗死后非运动组与脑梗死后运动组,另选30例正常老人作为对照组。脑梗死后非运动组患者采取常规治疗;脑梗死后运动组患者在常规治疗的基础上,进行减重步行训练。分别在脑梗死后1 w、4 w、2 m、3 m 4个时点检测外周血PDGF-BB水平,采用FMA运动量表评估下肢运动功能恢复情况。结果脑梗死后运动组患者其PDGF-BB水平在检测的4个时点均较脑梗死后非运动组高(P<0.05);脑梗死后运动组患者其下肢FMA评分从4 w(1 m左右)开始,均明显高于脑梗死后非运动组(P<0.05),且2 m时评分高于4 w(P<0.05)。相关性分析显示,脑梗死后运动组下肢FMA评分与血PDGF-BB水平存在正相关性(r=0.67)。结论减重步行训练极有可能通过促进PDGF-BB的分泌帮助脑梗死后下肢运动功能的恢复。Objective To explore the correlation of movement therapy and PDGF-BB to promote lower extremity motor function recovery in patient with cerebral infarction. Methods 73 cerebral infarction patients were randomly divided into two groups ,non-exercise group and exercise group, besides ,30 healthy elderly were selected as control. Patients in non-exercise group took conventional therapy,exercise group patients took the weight support treadmill training based on the eonveentional therapy. Plasma level of PDGF-BB was dected at 4 time point（ 1 w,4 w,2 m,3 m ） respectively,and the low extremity motor function re- covery was evaluated by FMA scale. Result PDGF-BB plasma level in patients with exercise group was higher than that in nonexercise group（P 〈0.05）;low extremity FMA score in paitents with exercise group was higher than that in non-exercise group from 4 w（P〈0.05） ,and the level at 2 m was higher than 2 w（P 〈0.05）. By corelation analysis,there was a positve correlaton between low extremity FMA score and plasma PDGF-BB level in paitents with exercise group. Conclusions Weight support treadmill training may help the lower extremity motor function recovery by promoting the secretion of PDGF-BB.

关 键 词：脑梗死 运动疗法 PDGF—BB 下肢运动功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]