420例别嘌醇不良反应的文献分析  

Literature Analysis of 420 Cases of Adverse Drug Reactions Induced by Allopurinol

作　　者：郑明节[1] 汤韧[1] 王春婷[1] 

机构地区：[1]国家食品药品监督管理总局药品评价中心,北京100045

出　　处：《中国药物警戒》2014年第4期225-228,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨别嘌醇致不良反应的一般规律特点,为临床合理用药提供参考。方法检索中国期刊全文数据库,对2013年之前国内公开发表有关别嘌醇致不良反应420例病例文献报道进行回顾性分析。结果老年男性患者发生率高,累及系统-器官主要为皮肤及其附件损害(42.33%)、全身性损害(22.77%)、肝胆系统损害(9.90%),严重皮肤系统的损害以多形红斑型药疹、剥脱性皮炎超敏综合征为主。结论别嘌醇片安全使用丞待加强,临床应重视别嘌醇的不良反应,加强用药监测,确保安全使用。Objective To probe into the status,characterstics and influencing factors of ADR cases induced by allopurinol, for providing a reference for chnical treatment. Methods Data were collected from domestic published literatures from ＂China Journal Full-text Database＂ before 2013, and 420 case reports of adverse drug reactions induced by allopurinol were analyzed retrospectively. Results Older male patients appear to be with a high rate. Organs involved mainly are skin and its appendages（42.33%）, systemic damage（22.77%）, hepatobiliary system damage（9.90%）. Severe damages to the skin are erythema multiforme system eruption, exfohative dermatitis and hypersensitivity syndrome. Conclusion AUopurinol should be used reasonably, and the monitoring of clinical use should be strengthened to ensure the safety of medication.

关 键 词：别嘌醇 药品不良反应 文献分析 

分 类 号：R971.1[医药卫生—药品] R994.111[医药卫生—药学]