依帕司他联合前列地尔对糖尿病周围神经病变患者神经病变主觉症状、血管功能、神经功能的影响  

Influence of epalrestat combined with alprostadil on neuropathy symptoms, blood vessel function, neurological function of patients with diabetic peripheral neuropathy

作　　者：黄云飞[1] 黄春[1] 宋玉玲[1] 罗秋玉 刘洁[1] 

机构地区：[1]广东省湛江中心人民医院内分泌科,广东湛江524037

出　　处：《中国现代医生》2014年第11期31-33,36,共4页China Modern Doctor

摘　　要：目的探讨依帕司他联合前列地尔对糖尿病周围神经病变患者神经病变主觉症状、血管功能、神经功能的影响。方法将糖尿病周围神经病变患者纳入研究对象,随机分为给予依帕司他联合前列地尔治疗的观察组和单独给予依帕司他治疗的对照组,比较神经病变主觉症状TSS评分、血管功能指标、神经功能指标。结果观察组神经病变主觉症状麻木、刺痛、烧灼感、感觉异常、总分分别为(1.02±0.4)分、(1.08±0.45)分、(1.14±0.36)分、(1.32±0.44)分、(4.58±1.16)分,正中神经、腓浅神经运动潜伏期分别为(3.1±0.6)ms、(2.7±0.5)ms,明显低于对照组,运动传导速度为(51.3±8.9)m/s、(53.4±7.4)m/s、感觉传导速度(53.2±6.9)m/s、(51.8±7.7)m/s,明显高于对照组(P<0.05)。结论依帕司他联合前列地尔治疗能够有效缓解神经病变主觉症状,改善血管功能和神经功能,具有积极的临床价值。Objective To study the impact of neuropathy symptoms, blood vessel function, neurological function of epalrestat combined with alprostadil in treating diabetic peripheral neuropathy. Methods The diabetic peripheral neuropathy patients were enrolled and randomly divided into observation group given epalrestat combined with alprostadil and control group only given alprostadil. Then TSS score, vascular function index, nerve function index were compared. Results Observation group numbness, tingling, burning sensation, paresthesia, total score were （1.02±0.4） scores, （1.08±0.45） scores, （1.14±0.36） scores, （1.32±0.44） scores, （4.58±1.16） scores respectively, median nerve, superficial peroneal nerve motor latency were （3.1±0.6）ms, （2.7±0.5） ms, were significantly lower than the control group, MNCV were （51.3± 8.9）ntis, （53.4±7.4） m/s, SNVC were （53.2±6.9）m/s, （51.8±7.7） m/s, were significantly higher than control group （P 〈 0.05）. Conclusion Epalrestat combined with alprostadil treatment can effectively relieve neuropathy symptoms, improve vascular function and neural function, have positive clinical value.

关 键 词：糖尿病周围神经病变 依帕司他 前列地尔 TSS评分 血管功能 神经功能 

分 类 号：R587.2[医药卫生—内分泌]