去甲肾上腺素对感染性休克患者肺循环压力的影响  

Effect of methylepinephrine on pulmonary circulation of septic shock

作　　者：汪建英[1] 朱克毅[1] 徐雁[1] 

机构地区：[1]杭州市肿瘤医院ICU,浙江杭州310002

出　　处：《中国现代医生》2014年第13期56-58,共3页China Modern Doctor

基　　金：浙江省医学会临床科研基金(2012ZYC-A72)

摘　　要：目的探讨去甲肾上腺素在治疗感染性休克时对患者肺血管压力的影响。方法随机将60例感染性休克患者分为4组,每组15例。分别输注不同剂量去甲肾上腺素,观察肺动脉压和肺静脉压的变化。结果当用药剂量达到2μg/(kg·min)和5μg/(kg·min)时肺动脉压显著升高,而平均动脉压在用药剂量达到1.0μg/(kg·min)时就显著升高。当用药剂量达到2μg/(kg·min)和5μg/(kg·min)时平均动脉压升高幅度显著高于肺动脉压升高幅度。结论去甲肾上腺素治疗感染性休克不升高肺静脉压,当剂量达到2μg/(kg·min)和5μg/(kg·min)时,肺动脉压升高,但其幅度低于平均动脉压的升高幅度。Objective To discuss effect of methylepinephrine on pulmonary circulation of septic shock. Methods Se- lected 60 cases with septic shock were divided into 4 groups, each of 15 cases, and were treated by different dose of methylepinephrine. PAP and PVP were detected and compared. Results PAP increased apparently at dose of 2μg/（kg·min） and 5μg/（kg·min）, and SAP increased apparently at dose of 1.0μg/（kg·min）. Ranges of SAP increasing at 2μg/ （kg· min） and 5μg/（kg·min） were higher than those of PAP. Conclusion Methylepinephrine for septic shock will not increase PVP, and increases PAP at dose of 2μg/（kg·min） and 5μg/（kg·min）, but ranges of SAP increasing are higher than PAP.

关 键 词：感染性休克 去甲肾上腺素 肺动脉压 肺静脉压 

分 类 号：R459.7[医药卫生—急诊医学]