真菌性阴道炎假丝酵母菌属临床感染及药敏结果分析  

Fungal vaginitis candida clinical infection and drug susceptibility: Results analysis

作　　者：赵辉[1] 王群[1] 赵冰[1] 薛宏[1] 张秀玲[2] 

机构地区：[1]沈阳医学院附属第二医院检验科,辽宁沈阳110001 [2]沈阳医学院附属第二医院妇产科,辽宁沈阳110001

出　　处：《中国现代医生》2014年第13期78-79,95,共3页China Modern Doctor

摘　　要：目的对真菌性阴道炎假丝酵母菌属临床感染情况及药敏结果进行分析,为临床抗真菌性阴道炎的治疗提供可靠的实验室依据。方法对288例阴道分泌物标本进行涂片镜检,阳性标本采用沙氏培养基进行真菌的分离,用ATB Expression全自动鉴定仪及其配套的鉴定板进行真菌培养鉴定和药敏试验。结果 288例阴道分泌物标本共检出真菌阳性55例;培养分离出假丝酵母菌属5种共55株,其中以白假丝酵母菌为主,共42株,占76.36%,其次为光滑假丝酵母菌6株,占10.91%;假丝酵母菌属对伊曲康唑的耐药率较高为46.46%,对两性霉素B敏感性最好,耐药率为7.27%。结论真菌性阴道炎患者阴道分泌物中,真菌感染以白假丝酵母菌为主;真菌对常用的抗真菌药物除两性霉素B敏感性较高外,对其他几种药物均存在不同程度的耐药。Objective To provide the clinical treatment of the resistance to fungal vaginitis reliable laboratory basis by analyzing fungal vaginitis candida clinical infections and drug susceptibility results. Methods Specimens of 288 cases of vaginal secretions were smear microscopy, which the positive specimens were separated by using ShaShi medium to fungi. Fungal culture identification and drug sensitive test were assayed by ATB Expression automatic identifying appa- ratus and its matching identification plate. Results Positive fungus 55 cases were detected from 288 cases of vaginal discharge specimens , white candida was given priority among them, a total of 42 strains, accounting for 76.36%, followed by smooth candida strains, 6 （10.91%）; Itraconazole resistance rates were 46.46%, the best sensitivity to amphotericin B, the resistance rate of 7.27%. Conclusion Fungal vaginitis vaginal secretions in the patients, fungal infection is given priority to with white candida; Fungi to common antifungal drugs except amphotericin B sensitivity is higher for several other drugs have different degrees of resistance.

关 键 词：阴道炎 白假丝酵母菌 药物敏感性实验 

分 类 号：R711.3[医药卫生—妇产科学]