退黄方加减治疗黄疸患者60例临床观察  

Clinical Observation on Modified Tuihuang Formulas( Jaundice-Subsidising Formula,退黄方) for 60 Cases of Jaundice

作　　者：刘晓燕[1] 辛绍杰[1] 陈婧[1] 肖珑[1] 杨昊臻[1] 童晶晶[1] 柳芳芳[1] 胡瑾华[1] 

机构地区：[1]中国人民解放军第三〇二医院肝衰竭诊疗与研究中心,北京市100039

出　　处：《中医杂志》2014年第9期759-761,共3页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81171641)

摘　　要：目的观察退黄方治疗黄疸的临床疗效。方法将120例黄疸患者随机分为治疗组和对照组各60例。对照组给予常规治疗(静脉注射、口服保肝、退黄药物),治疗组在常规治疗(除苦黄注射液)基础上,另口服退黄方随证加减,每日1剂。两组患者均治疗4周。治疗前后对两组患者的临床症状进行评分,检测肝功能指标[胆碱酯酶(CHE)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、总胆红素(TBiL)]、凝血酶原活动度(PA),评价两组患者的临床疗效。结果治疗组临床疗效总有效率为85.00%,对照组为73.33%,两组比较差异无统计学意义(P>0.05)。两组患者治疗后ALT、AST、TBiL及症状积分均明显下降(P<0.01);对照组治疗后CHE明显下降(P<0.05),且显著低于治疗组(P<0.05)。结论退黄方加减联合常规治疗能明显降低黄疸患者TBiL,稳定CHE,改善肝功能,缓解临床症状。Objective To observe the therapeutic effect of Tuihuang Formulas （Jaundice-Subsidising Formula,退黄方） for jaundice. Methods Totally 120 cases of jaundice were randomized into the treatment group and con- trol group, with 60 in each. The control group was given conventional intravenous infusion and oral medication for jaundice. The treatment group was given Tuihuang Formulas （Jaundice-Subsidising Formula, ~） one dose daily and conventional therapy same as the control group except Kuhuang Injection. Both groups were treated for 4 weeks. The symptoms were scored before and after treatment in both groups. The levels of cholinesterase （ CHE）, alanine aminotransferase （ ALT）, aspartate aminotransferase （ AST）, total bilirubin （TBiL） and prothrombin activity（PA） were detected. The efficacy was evaluated after treatment. Results The total effective rate of the treatment group and control group was 85.00% and 73.33% respectively, with no significant difference between groups （P 〉 0. 05 ）. The levels of ALT, AST and TBiL and symptom scores were significantly decreased in both groups after treatment （P 〈 0. 01 ）. CHE in the control group decreased significantly after treatment, and was lower than that of the treat- ment group （P 〈 0. 05 ）. Conclusion Tuihuang Formulas （ Jaundice-Subsidising Formula, ~ ~） combined with conventional therapy can obviously reduce TBiL, stabilize CHE, improve liver function and relieve symptoms.

关 键 词：退黄方 黄疸 慢性肝炎 肝硬化 肝衰竭 

分 类 号：R259[医药卫生—中西医结合]