基于Heckel方程的药物粉体压缩特性的理论分析与实验研究  

Theoretical Analysis and Experimental Research of Pharmaceutical Powder Compression Characteristics Base on the Heckel Equation

作　　者：佀国宁[1] 陈岚[1] 张京红[1] 谭中华[1] 谢蕴辉 

机构地区：[1]上海理工大学医疗器械与食品学院,制药技术与设备研究所,上海200093

出　　处：《中国药学杂志》2014年第9期746-752,共7页Chinese Pharmaceutical Journal

基　　金：上海市高校选拔培养优秀青年教师科研专项资助项目(5113308102)

摘　　要：目的基于Heckel粉体压缩方程,建立了含有多种成分和不同比例的药物粉体混合物压缩特性的通用理论预测模型。方法分别对乳糖、淀粉、微晶纤维素和磷酸氢钙4种辅料进行了单向压缩实验,得到了相应的Heckel方程参数,同时对含有5种不同药物比例的辅料混合物进行了单向压缩实验,得到了混合物密度、泊松比随压力的变化曲线和Heckel方程曲线,把理论预测模型结果与实验结果进行对比。结果分析表明,不同比例混合物的孔隙率和Heckel方程纵坐标误差绝对值均保持在4%以内,密度的误差绝对值在2.5%以内,从而验证了该理论模型能够用于预测多元药物粉体压缩的特性。结论该模型具有通用性,能够用于预测任意比例和多成分药物粉体的压缩特性。OBJECTIVE To built a general theoretical prediction model of pharmaceutical powder mixtures with different components and mass fraction base on powder compaction Heckel equation. METHODS Uniaxial compression tests were con ducted with four excipients, and the Heckel equation parameters were got. The uniaxial compression tests of mixtures with differ ent mass fraction were conducted; the change laws of density and porosity with applied pressure and the Heckel equation curves were obtained. RESULTS The comparison of theoretical prediction model and experimental results showed that the porosity er ror and the Heckel vertical coordinate error were less than 4% and the density error was less than 2.5%. CONCLUSION The established model has universality to predict the compression characteristics of multicomponent powders of any proportion composition.

关 键 词：Heckel方程 药物粉体压缩 多元混合物 预测模型 

分 类 号：R944.4[医药卫生—药剂学]