菟丝子提取物对亚急性衰老小鼠的抗衰老作用研究  

Research on the Anti-aging Action of the Extracts of Cuscuta Chinensis in Subacute Aging Mice

作　　者：刘海云[1] 吴欢欢[2] 何志坚[3] 

机构地区：[1]江西中医学院,南昌330004 [2]江西中医学院科技学院,南昌330009 [3]江西省肿瘤医院,南昌330029

出　　处：《江西中医学院学报》2013年第6期72-74,共3页Journal of Jiangxi College of Traditional Chinese Medicine

基　　金：江西省教育厅青年科学基金项目(项目编号:GJJ12541);江西省卫生厅中医药科研基金项目(项目编号:2011A137);江西中医学院校级课题项目(项目编号:2012ZR046)

摘　　要：目的:研究菟丝子提取物对实验性衰老小鼠的抗衰老作用及机制。方法:以D-半乳糖致亚急性衰老小鼠为模型,同时给予灌胃不同浓度的菟丝子提取物,6周后,采用比色法测定肝脏和脑组织超氧化物歧化酶(SOD)、丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-PX)活性来研究菟丝子延缓衰老的作用。结果:菟丝子提取物能显著增加肝脏和脑组织中SOD和GSH-Px活性,降低其MDA含量。结论:菟丝子提取物抗衰老作用可能通过提高抗氧化酶SOD、GSH-PX活力,降低脂质过氧化物MDA含量而实现。Objective： To observe the Anti -aging activity of the extracts of C. chinensis in the experimental aging mice. Method：The sub acute aging mice model by D -galactose（D -gal） were given the extracts of C. chinensis via i.g. gtt. After 6 weeks, the colorimetric method was used to determine the cellular content of malondialdehyde （MDA）, the enzyme activity of superoxide dismutase （SOD） and glutathione peroxidase（ GSH -PX）. Results：Aqueous extract of C. chinensis could improve the activities of SOD, GSH -Px to different degree and decrease the contents of MDA. Conelusiou：The anti -aging activity of the extracts of C. chinensis is achieved by improving the activity of SOD and GSH - PX,and lowering the contents of MDA.

关 键 词：菟丝子提取物 D-半乳糖 衰老小鼠 SOD MDA GSH-PX 

分 类 号：R285.5[医药卫生—中药学]