复方穿蛭透皮贴的制备及其体外透皮吸收、释放度研究  

Study on preparation and in vitro release characteristics of Compound Chuanzhi Transdermal Patch

作　　者：王丽娜[1] 陈来祥 王冬梅[1] 宋红敏[1] 齐佳悦[1] 王新成[1] 

机构地区：[1]吉林医药学院,吉林吉林132013 [2]空军开原场站卫生队,沈阳铁岭112000

出　　处：《时珍国医国药》2014年第4期863-864,共2页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省教育厅重点资助项目(No.吉教科合字[2011]第283号)

摘　　要：目的制备复方穿蛭透皮贴并考察其体外透皮吸收和释放度行为,为其制剂开发提供依据。方法以聚丙烯酸酯、氮酮、丙二醇、薄荷醇为材料制备复方穿蛭透皮贴,按《中国药典》方法测定体外释放度,采用改良Franz扩散池考察透皮贴的体外释放性能。结果复方穿蛭透皮贴的体外释药符合零级动力学方程。结论复方穿蛭透皮贴制备工艺简单,具有良好的体外经皮渗透作用。Objective To prepare the Compound Chuanzhi Transdermal Patch and study its percutaneous absorption and in vitro release. Methods Polyacrylate, azone, propanediol and menthol were employed to prepare the patch. Modified Franz diffusion cell was used in the percutaneous absorption tests. The in vitro release was studied according to the requirement of Chinese Pharmaco- poeia（2010）. Results The release mechanism of the Patch in vitro coincided with zero- order Equation. Conclusion The Com- pound Chuanzhi Transdermal Patch can be prepared feasibly and has good in vitro permeation property.

关 键 词：复方穿蛭透皮贴 体外释放 透皮吸收 

分 类 号：R283[医药卫生—中药学]