加倍剂量左西替利嗪治疗慢性自发性荨麻疹的疗效观察及三磷酸肌醇血清含量的检测  

Efficacy Observation of Triple Dose of Levocetirizine in the Treatment of Chronic Spontaneous Urticaria and Determination of Serum Concentration of Inositol Triphosphate

作　　者：李朝阳[1] 孙仁山[1] 李菁[1] 宋君[1] 伍津津[1] 杨涛[1] 唐辉[1] 唐书谦[1] 李凤[1] 杨永强[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所皮肤科,重庆400042

出　　处：《中国药房》2014年第18期1674-1676,共3页China Pharmacy

基　　金：国家自然科学基金资助项目(No.30972647)

摘　　要：目的:探讨加倍剂量的左西替利嗪治疗慢性自发性荨麻疹的疗效及三磷酸肌醇(IP3)在慢性自发性荨麻疹(CSU)发病中的作用。方法:选取对常规抗组胺药物效果不佳的CSU患者15例,给予3倍剂量左西替利嗪(15 mg、qd),通过治疗前和治疗7 d后荨麻疹活动性评分(UAS)观察其临床应用效果;采用酶联免疫吸附法检测治疗前和治疗7 d后血清中IP3的含量,并与15例正常人血清IP3含量作对照。结果:15例患者治疗7 d的有效率达100%,4例患者临床症状完全消失。慢性自发性荨麻疹患者治疗前、治疗7 d后及对照组血清中的IP3浓度分别为(43.54±41.97)、(18.40±17.53)、(1.31±0.92)pg/ml;3组血清IP3含量之间差异均有统计学意义(P<0.05)。结论:对于慢性自发性荨麻疹,3倍剂量左西替利嗪疗效显著,未见明显副作用。IP3与疾病的严重程度呈正相关,参与CSU的发病机制。OBJECTIVE： To observe the effects of triple dose of levocetirizine for chronic spontaneous urticaria （CSU）, and to explore the effects of inositol triphosphate （IPJ） during the pathogenesis of CSU. METHODS： 15 cases of CSU were given 3-tbld dose of levocetirizine 15 rag, qd, for 7 days after conventional antihistamine therapy failure. Clinical efficacy of levocetiri- zinc was observed by using UAS before treatment and 7 day after treatment. The contents of IP3 in serum were determined by ELISA belbre treatment and 7 days after treatment, and compared with those of 15 healthy volunteers. RESULTS： The effective rate of levocetirizine therapy was 100% after 7-day treatment. Among these patients, 4 cases were completely recovered. The se- rum concentration of IP3 in CSU patients were （43.54 ± 41.97） pg/ml before treatment and （18.40 ± 17.53） pg/mL after 7-day treatment; that of control group was （1.31 ± 0.92） pg/mL. The average serum concentration of IP3 had statistical significance among 3 groups （P〈0.05）. CONCLUSIONS： 3-folds dose of levocetirizine is significantly effective for CSU and had no signifi- cant side effect. The level of lP3 is correlated positively with CSU activity. It is showed that IP3 may take a very important role in the pathogenesis of CSU.

关 键 词：慢性自发性荨麻疹 左西替利嗪 三磷酸肌醇 加倍剂量 

分 类 号：R986[医药卫生—药品] R969.4[医药卫生—药学]