经颅多普勒超声动态评价他汀类药对急性缺血性卒中脑血流动力学的影响  

Effects of Statins on Cerebrovascular Hemodynamics of Acute Ischemic Stroke Patients Measured by Transcranial Doppler

作　　者：刘喷飓[1] 刘水平[1] 张晓婷[2] 

机构地区：[1]首都医科大学附属北京安贞医院神经内科,北京100029 [2]青岛市市南区人民医院,山东青岛266002

出　　处：《中国药房》2014年第18期1682-1684,共3页China Pharmacy

摘　　要：目的:评价他汀类药对存在颅内血管狭窄的急性缺血性卒中患者脑血流动力学的影响。方法:入选存在颅内血管狭窄的急性缺血性卒中患者161例,根据是否规律服用他汀类药(阿托伐他汀钙,20 mg/d),将其分为用药组(83例)与非用药组(78例)。入院1周内完成经颅多普勒超声(TCD)脑血流动力学评价,再分别于发病后4周和12周时再经TCD复查两组患者脑血流动力学情况。结果:与入院1周内的脑血流动力学情况比较,用药组患者的大脑中动脉(MCA)脑血流动力学逐步改善,在4周时差异无统计学意义,但12周时差异达到统计学意义(P<0.05);发病后4、12周两次复查,用药组患者对MCA狭窄的改善均高于非用药组,但这种差异只在发病12周时差异达到统计学意义(P<0.05)。结论:他汀类药对改善存在颅内血管狭窄的急性缺血性卒中患者的脑血流动力学有一定作用。OBJECTIVE： To evaluate the effects of statins on cerebrovascular hemodynamics of acute ischemic stroke patients with intracranial arterial stenosis. METHODS： 161 acute ischemic stroke patients with intracranial arterial stenosis were divided in- to treated group （83 cases） and untreated group （78 cases） according the situation of regular administration of statins （atorvastatin calcium, 20 mg/d）. Cerebrovascular hemodynamics was evaluated by transcranial Doppler （TCD） within a week after admission. The cerebrovascular haemodynamics was rechecked in 2 groups by TCD 4 and 12 weeks after stroke attack. RESULTS： Compared to within a week after admission, the cerebrovascular haemodynamics of middle cerebral artery （MCA） in treated group were im- proved gradually; the difference had no statistical significance at 4th week, but the difference had statistical significance at 12th week （P〈0.05）. The arterial stenosis of MCA in treated group was improved significantly 4 and 12 weeks after stroke attack, com- pared with untreated group; there was statistical significance at 12th week （P〈0.05）. CONCLUSIONS： Statins may improve the cerebrovascular haemodynamics of acute ischemic stroke patients with intracranial arterial stenosis.

关 键 词：经颅多普勒超声 他汀类药 卒中 大脑中动脉 

分 类 号：R972.6[医药卫生—药品] R743.3[医药卫生—药学]