广东省223例抗结核药不良反应报告分析  

Analysis of 223 ADR Cases Caused by Anti-tuberculosis Drugs in Guangdong Province

作　　者：李祥[1] 陶涛[1] 王宏[2] 

机构地区：[1]广州市胸科医院药剂科,广州510095 [2]广东省药品不良反应监测中心,广州510080

出　　处：《中国药房》2014年第18期1690-1692,共3页China Pharmacy

摘　　要：目的:了解广东省基层结核病防治机构抗结核药不良反应(ADR)的发生情况,为临床结核病的防治提供参考。方法:采用回顾性和描述性研究方法,对广东省药品不良反应监测中心在2012年度收集的省内基层结核病防治医疗机构上报的抗结核药ADR报告223例进行统计、分析。结果:223例ADR报告以男性患者为主(69.06%);口服制剂引发的ADR居多,占93.72%;各类抗结核药引起的ADR以药物性肝功能损害为主(占79.84%),其次为全身性损害(占8.23%);严重的ADR有47例(占21.08%);大部分ADR都有较好的转归,对原患疾病的影响也较小。结论:抗结核药引发的ADR较多,长期的服药将会影响患者的依从性。临床应重视ADR并及时发现和治疗,以取得更好的临床效果。OBJECTIVE： To investigate the occurrence of ADR induced by anti-tuberculosis drugs in primary institutions from Guangdong province, and to provide reference for the prevention and treatment of tuberculosis. METHODS： By retrospective and descriptive study, a total of 223 cases of anti-tuberculosis drug caused ADR reports collected by Guangdong Center for ADR Moni- toring in 2012 were analyzed statistically. RESULTS： Among 223 ADR reports, 69.06% of ADR patients were male, 93.72% drugs were taken orally, and main ADR was drug-induced liver injury （79.84%）, followed by systemic injury （8.23%） ; there were 47 severe ADR （21.07 % ） ; most ADR were well healed and had little effect on primary disease. CONCLUSIONS： Anti-tuber- culosis drugs could cause many ADR, and long-term medication influence patients＇ compliance. Great importance should be at- tached to ADR so as to timely find and treat ADR and achieve sound therapeutic efficacy.

关 键 词：抗结核药 药品不良反应 监测 报告 

分 类 号：R969.3[医药卫生—药理学] R978.3[医药卫生—药学]