乙型肝炎病毒携带孕产妇母婴传播的影响因素分析  

Analysis on the Influence Factors of Maternal-neonatal Transmission of Maternal Hepatitis B Virus Carriers

作　　者：李维茹[1] 黄沛清[1] 简艳红[1] 

机构地区：[1]广东省佛山市第一人民医院妇产科,广东佛山528000

出　　处：《中国医药指南》2014年第11期3-3,5,共2页Guide of China Medicine

基　　金：2013年佛山市医学科学技术研究项目(编号:2013009)

摘　　要：目的分析研究乙型肝炎病毒携带孕产妇母婴传播的影响因素。方法选取2010年3月至2013年4月收治的251例乙型肝炎病毒携带孕产妇为研究对象,将其中新生儿感染率进行统计,并比较不同生产方式、产前阻断情况、母体HBV DNA检测情况、喂养方式及疫苗接种时间者的感染率,并对其以Logistic分析进行处理。结果 251例产妇中共发生13例新生儿感染,感染率为5.18%,不同喂养方式新生儿的感染率无显著性差异,P>0.05,而未进行产前阻断、母体HBV DNA阳性、阴道顺产及出生后未24 h内接种疫苗者的感染率均高于其他,且经Logistic分析显示其均为高危因素,P均<0.05,均有显著性差异。结论未进行产前阻断、母体HBV DNA阳性、阴道顺产及出生后未24 h内接种疫苗均是乙型肝炎病毒携带孕产妇母婴传播的危险因素,应注意对上述方面的控制。Objective To study and analyze the inlfuence factors of maternal-neonatal transmission of maternal hepatitis B virus carriers. Methods 251 maternal hepatitis B virus carriers from March 2010 to April 2013 were selected as research object, and then the neonatal infection rate was analyzed, and the infection rates of different delivery modes, prenatal blockade state, maternal HBV DNA detection, feeding patterns and vaccination time were compared, and the correlation better those indexes and infection was analyzed by logistic analysis. Results 13 newborns of 251 puerpera were with infection, the infection rate was 5.18%, and the infection rates of newborns with different feeding patterns had no signiifcant differences, P＆gt;0.05, but the puerpera without prenatal blockade state, with HBV DNA positive, spontaneous vaginal delivery and newborns without vaccination in 24 h after delivery were higher than those of others, and those indexes were all the risk factors by Logistic analysis, all P＆lt;0.05, there were all signiifcant differences. Conclusion The puerpera without prenatal blockade state, with HBV DNA positive, spontaneous vaginal delivery and newborns without vaccination in 24 h after delivery are all the risk factors of maternal-neonatal transmission of maternal hepatitis B virus carriers, and the indexes should be paid enough control.

关 键 词：乙型肝炎病毒携带孕产妇 母婴传播 影响因素 

分 类 号：R512.62[医药卫生—内科学]