妊娠合并亚临床甲状腺功能减退症1053例临床分析  

Clinical analysis of subclinical hypothyroidism during pregnancy in 1 053 cases

作　　者：康苏娅[1] 汪云[1] 伍理[1] 

机构地区：[1]南京医科大学附属苏州医院,江苏苏州215002

出　　处：《中国妇幼健康研究》2014年第2期252-253,262,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的研究亚临床甲状腺功能减退(SCH)对孕期并发症及妊娠结局的影响。方法选取经甲状腺功能筛查诊断为SCH的孕妇1 053例(SCH组),正常孕妇3 899例(对照组),比较各组TSH、FT4、TPOAb,孕期并发症及妊娠结局情况。结果SCH组的TSH水平及TPOAb阳性率均高于对照组(t=39.001,P<0.01;x^2=40.753,P<0.01)。SCH组的早产率及新生儿窒息率高于对照组(x^2=8.638,P<0.05;x^2=22.209,P<0.01),SCH组新生儿低出生体重率高于对照组,但无统计学意义(x^2=2.323,P>0.05)。结论 SCH是孕期常见病,可能与流产、早产等妊娠不良结局的发生相关,应重视妊娠妇女的SCH筛查。Objective To investigate the influence of subclinical hypothyroidism （ SCH ） on complications and pregnancy outcomes . Methods A retrospective chart review was performed on 1 053 pregnant women with SCH （ SCH group ） and 3 899 pregnant women with normal thyroid function （ control group ） diagnosed by serum thyroid function screening .The following parameters of two groups were compared：serum levels of TSH, FT4 and TPOAb, maternal complications and pregnancy outcomes .Results Serum TSH level of SCH group was higher than control group （t=39.001,P〈0.01） and TPOAb positive rate was higher in SCH group （χ2 =40.753,P〈0.01）. The incidences of premature delivery and neonatal asphyxia were higher in SCH group （χ2 =8.638,P〈0.05;χ2 =22.209,P〈0.01）.The incidence of neonatal low birth weight was higher in SCH group , but the difference showed no statistical significance （χ2 =2.323,P〉0.05）.Conclusion SCH is common in pregnant women .It maybe contribute to adverse pregnancy outcomes such as abortion and premature.More attention should be paid on SCH screening in pregnant women .

关 键 词：亚临床甲状腺功能减退 妊娠期糖尿病 妊娠期高血压 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]