单剂量肌注维生素D_3对维生素D缺乏孕妇及其新生儿作用的研究  

Intervention of a single dose of intramuscular injection of vitamin D_3 on vitamin D deficiency in pregnant women and neonates

作　　者：刘科莹[1] 潘建平[2] 王粉玲 

机构地区：[1]西安医学院附属北方医院,陕西西安710043 [2]西安交通大学医学院,陕西西安710061

出　　处：《中国妇幼健康研究》2014年第2期279-281,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的：通过对维生素D缺乏孕妇进行单次、单剂量肌注补充维生素D，对其有效性和安全性进行研究。方法检测孕妇维生素D水平，将60例维生素D缺乏的孕妇随机分为干预组和对照组各30例。对干预组孕妇在其36～38孕周时，进行一次性肌注维生素D37．5mg（30万单位），分析比较干预组与对照组的孕妇及其新生儿血清维生素D水平。结果产时（干预后）干预组孕妇的血清25-（OH）D高于对照组，差异有统计学意义（t＝6．13，P＜0．05）；干预组新生儿的血清25-（OH）D也高于对照组，差异有统计学意义（t＝4．99，P＜0．05）。干预组孕母和新生儿脐血25-（OH）D水平呈正相关（r＝0．53，P＜0．05）；对照组孕母和新生儿脐血25-（OH）D水平也呈正相关（r＝0．63，P＜0．05）。结论孕妇、新生儿体内维生素D水平普遍比较低，单剂量肌注补充维生素D3的干预措施对改善孕妇及其新生儿维生素D的状况有效并且安全。objective To determine the effectiveness and safety of a single dose of intramuscular injection of vitamin D in pregnant women . Methods The serum vitamin D level of pregnant women was measured .Sixty pregnant women of vitamin D deficiency were randomly divided into two even groups：intervention group and control group .The intervention group received disposable intramuscular injection of vitamin D3 7.5mg （300,000 units） during their 36-38 weeks of gestation , and the serum vitamin D level of pregnant women and neonates were compared between intervention group and control group .Results The 25-（ OH） D serum levels of pregnant women and neonates in the intervention group were significantly higher than those in the control group （t value was 6.13 and 4.99, respectively, both P〈0.05）.The 25-（ OH） D level in pregnant women was positively correlated with that in neonates cord blood in intervention group and control group （ r value was 0.53 and 0.63, respectively, both P〈0.05）.Conclusion The level of vitamin D in pregnant women and neonates is generally low.A single dose of intramuscular injection of vitamin D 3 is effective and safe in improving vitamin D status both in pregnant women and neonates .

关 键 词：孕妇 新生儿 肌注 临床干预 

分 类 号：R714.7[医药卫生—妇产科学]