静脉滴注声学造影剂定量心肌血流的方法学研究  

Studies on Methodology of Quantitative Measurement of Myocardial Blood Flow with Continuous Intravenous Injection of Sonicated Microbubbles

作　　者：查道刚[1] 李喆[2] 黄晓波[1] 张稳柱[1] 金伟军[3] 谢志泉[1] 冯力[1] 宾建平[1] 刘伊丽[1] 

机构地区：[1]广州第一军医大学南方医院心内科,510515 [2]第一军医大学工系 [3]南方医院药局

出　　处：《中国超声医学杂志》2001年第2期85-88,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金! (No. 39870 32 9)资助

摘　　要：目的 :建立持续滴注声振微泡定量心肌血流灌注的方法学。方法 :采用不同滴注速度经犬外周静脉注射微泡造影剂 ,根据心肌显影效果判定最佳滴注速度。同时重点观察应用心脏程序刺激仪或自制心电触发辅助仪克服现有超声仪器心电触发间隔长度不足的效果。结果 :1除 0 .5 ml/min滴注组心肌显影略淡 ,6 ml/min滴注组造影过程中偶见远场轻度衰减 ,其余两组心肌显影效果佳 ;2应用心脏程序刺激仪或自制心电触发辅助仪可使超声仪器心电触发间隔由 9个心动周期稳定延长至 45个心动周期。结论 :11～ 2 ml/min滴注组心肌显影效果好 ,且其所需造影剂剂量明显低于 6 ml/min滴注组 ,建议使用 ;2心脏程序刺激仪及自制心电触发辅助仪均可有效克服现有超声仪器心电触发间隔长度不足的问题 ,但心脏程序刺激仪操作略繁琐 ,建议使用后者。Objective:Intermittent imaging with gradually prolonged trigger interval,when sonicated microbubbles were injected continuously,was used for quantitative measurement of myocardial blood flow with myocardial contrast echocardiography(MCE).The trigger intervals set in the different echo system were 9 11 cardiac cycles,but the intermittent period was not long enough to fulfill the measurement.This study is to test the efficacy in application of a cardiac programming stimulator or a self made trigger extension apparatus for lengthening the trigger interval during blood flow estimation with MCE.Methods:Four different continuous injection rates(0 5 ml/min,1 0 ml/min,2 0 ml/min,and 6 0 ml/min)with sonicated microbubbles were applied to observe the contrast effect in 6 dogs.On the same time,cardiac programming stimulator or self made trigger extension apparatus was used to lengthen the trigger interval of ultrasonic apparatus.Results:Contrast effect was weak in the group of 0 5ml/min,but some mild attenuation in the far zone was occasionally found in the group of 6 ml/min.The other two groups,1 ml/min and 2ml/min group,had well contrast effect without attenuation.Both cardiac programming stimulator and self made trigger extension apparatus could lengthen the trigger interval from 9 cardiac cycles to 45 cycles.Conclusions:Continuous infusion rate of 1 ml/min or 2 ml/min is optimal for myocardial perfusion quantification.Both cardiac programming stimulator and sefl made trigger extension apparaturs are useful to lengthen the ECG trigger interval.

关 键 词：造影超声心动图 持续滴注法 心肌灌注 声学造影剂 静脉滴注 心肌血流 

分 类 号：R814.43[医药卫生—影像医学与核医学]