活性炭负载P-TsOH催化超声合成阿司匹林  

Synthesis of Aspirin Catalyzed by Activated Carbon Supported p-TsOH under Ultrasonic Radiation

作　　者：刘天宝[1] 彭艳芬[1] 王云[1] 邹传同 刘小四[1] 汪新[1] 

机构地区：[1]池州学院材料与化学工程系,安徽省池州市牧之路199号247000

出　　处：《光谱实验室》2014年第3期414-417,共4页Chinese Journal of Spectroscopy Laboratory

基　　金：国家自然科学基金资助项且（21271035）;地方高校国家级大学生创新创业训练计划项目（201311306003,201211306025）：安徽省大学生刨新创业训练计翅I项目（AH201311306003）

摘　　要：以水杨酸和乙酸酐为原料，以活性炭负载对甲苯磺酸（p-TsOH）为催化剂，在超声作用下催化合成阿司匹林。考察了反应时间，催化剂用量，酐、酸摩尔比以及反应温度对该反应的影响。实验结果表明：活性炭负载p-TsOH有着良好的催化活性，当反应条件为：超声时间为14min，反应温度为90℃，酐、酸摩尔比为3．5：1，催化剂用量为水杨酸物质量的2．5％时，阿司匹林的收率可达83％。Aspirin had been synthesized by ultrasonic radiation, using salicylic acid and acetic acid anhydride as raw materials and activated carbon supported p-toluenesulfonic acid （p-TsOH） as a catalyst. The effects of reaction time, the amount of catalyst, the mole ratio of salicylic acid to acetic acid anhydride and reaction temperature on the yield of aspirin were investigated. The experimental results showed that activated carbon supportedp-TsOH had good catalytic activity. The optimal conditions were as follows： a reaction time of 14 min, a reaction temperature of 90℃, and an acetic acid anhydride / salicylic acid molar ratio of 3.5：1. The yield of aspirin reached up to 83% when the amount of catalyst was 2.5% of the dosage of salicylic acid.

关 键 词：阿司匹林 活性炭负载p-TsOH 超声 合成 

分 类 号：O623.67[理学—有机化学]