监测胚胎移植后第4天P/E_2比值对黄体支持的参考意义  

The reference significance of monitoring of progesterone/estradiol ratio on the fourth day after embryo transfer for luteal support

作　　者：许浩丽[1] 杨桂艳[1] 杨嫦玉[1] 梁英婴[1] 张丽娜[1] 

机构地区：[1]广东省珠海市妇幼保健院生殖中心,519000

出　　处：《中国妇幼保健》2014年第14期2206-2209,共4页Maternal and Child Health Care of China

摘　　要：目的：探讨胚胎移植后第4天P／E2比值对黄体支持的参考意义，从而指导临床治疗。方法：回顾性分析行IVF—ET／ICSI240周期不孕患者，所有患者均第一次接受IVF／ICSI，根据移植第4天P／E2比值分组，A组P／E2〈100，B组100≤P／E2〈200，C组P／E2≥200。比较各组的年龄、不孕年限和基础FSH、基础LH、基础E2、HCG日LH、HCG日P、HCG日E2、ET＋4dayE2、ET＋4dayP水平及成熟卵泡数、获卯数、优胚数、妊娠率、流产率。结果：ET＋4dayP水平B、C两组比较差异无统计学意义（P〉0．05），与A组两两比较，A组ET＋4dayP水平最低，差异有统计学意义（P〈0．01）；ET＋4dayE：水平A、B两组比较差异无统计学意义（P〉0．05），与C组两两比较，C组ET＋4dayE2水平最低，差异有统计学意义（P〈0．01）；B组妊娠率最高，C组妊娠率最低、流产率最高，差异有统计学意义（P〈0．05），其他指标差异无统计学意义（P〉0．05）。结论：E2／P比值在100～200之间提示黄体功能良好，有好的妊娠结局，对制定个体化的黄体支持方案有参考意义。Objective： To explore the guiding significance of progesterone/estradiol ratio on the fourth day after embryo transfer for luteal support, and direct clinical treatment. Methods： The infertile patients treated with IVF - ET/ICSI for the first time for 240 cycles were analyzed retrospectively, then they were divided into three groups according to progesterone/estradiol ratio on the fourth day after embryo transfer： group A （ progesterone/estradiol ratio 〈 100）, group B （ 100≤ progesterone/estradiol ratio 〈 200） and group C （ progesterone/es- tradiol ratio≥200） . The parameters in the three groups were compared, including age, the duration of infertility, basic follicle -stimula- ting hormone, basic luteinizing hormone, basic estradiol, LH level on the day of human chorionic gonadotropin （hCG） injection, progester- one level on the day of hCG injection, estradiol level on the day of hCG injection, estradiol level on the fourth day after embryo transfer, progesterone level on the fourth day after embryo transfer, the number of mature follicles, the number of retrieved oocytes, the number of high quality embryos, pregnancy rate and abortion rate. Results： There was no statistically significant difference in progesterone level on the fourth day after embryo transfer between group B and group C （ P 〉 0. 05 ）, progesterone level on the fourth day after embryo transfer in group A was the lowest among the three groups, there was statistically significant difference （P 〈 0. 01 ） ; there was no statistically significant differ- ence in estradiol level on the fourth day after embryo transfer between group A and group B （P 〉 0. 05）, estradiol level on the fourth day af- ter embryo transfer in group C was the lowest among the three groups, there was statistically significant difference （ P 〈 0. 01 ） ; the pregnancy rate in group B was the highest, while the pregnancy rate in group C was the lowest, the abortion rate in group C was the lowest, there were statistically sig

关 键 词：体外受精-胚胎移植 雌二醇 孕酮 黄体支持 

分 类 号：R711.6[医药卫生—妇产科学]