抗菌肽的临床应用与内源性表达调控研究进展  

Progress on Antimicrobial Peptides' Gene Endogenous Expression Regulation and Clinical Application

作　　者：陈红伟[1] 李英伦[2] 刘娟[1] 吴俊伟[1] 黄庆洲[1] 

机构地区：[1]西南大学动物医学系,重庆402460 [2]四川农业大学动物医学院,雅安625014

出　　处：《生物技术通报》2014年第4期25-29,共5页Biotechnology Bulletin

基　　金：中央高校基本科研业务费专项(XDJK2012C099);重庆市科委自然科学基金计划资助项目(cstc2012jjA80013)

摘　　要：抗菌肽是具有抗菌活性的一类短肽,具有分子量低、热稳定、广谱的抗菌、抗病毒及抑制肿瘤的生物活性,是动植物防御体系的一个重要组成部分,在机体抵抗病原的入侵方面起着重要的作用。但实践表明,作为抗生素替代品的抗菌肽的开发并非易事。针对近年来抗菌肽研究的热点,对抗菌肽的临床应用和表达调控进行了简要综述。Antimicrobial peptides are a group of small molecular proteins with antibacterial activities, which are key components of animal and vegetation defense system and play an important role in protecting body from invasion of pathogens. These peptides have many characters such as low molecular weight, thermostability. And they have the wide range of antibacterial, antiviral spectrum and inhibiting growth of tumor cells. However, the development of antimicmbial peptides as antibiotic substitutes is far from easy. The recent warm spots about antimicrobial peptides, especially gene expression regulation and clinical application were reviewed.

关 键 词：抗菌肽 Ⅲ期临床试验 基因表达调控 开发 策略 

分 类 号：R978.1[医药卫生—药品] Q51[医药卫生—药学]