阿托西班用于反复植入失败者行解冻胚胎移植的临床效果观察  

Influence of atoxiban on pregnancy outcome in patients with repeated implantation failure in freezing embryo transfer cycle

作　　者：张玥[1,2] 褚玉晶[1] 罗海宁[1] 张云山[1] 薛凤霞[2] 

机构地区：[1]天津医科大学妇产临床学院,300100 [2]天津医科大学总医院

出　　处：《中国计划生育学杂志》2014年第5期325-328,共4页Chinese Journal of Family Planning

摘　　要：目的:观察阿托西班用于胚胎反复植入失败(RIF)者行解冻胚胎移植(FET)的临床效果。方法:回顾性分析在天津市中心妇产科医院生殖医学中心行FET的RIF患者240例,FET前1h静脉给予37.5mg阿托西班的120例患者为观察组,移植前不应用阿托西班的120例患者为对照组。比较两组胚胎着床率、临床妊娠率、多胎率、流产率、异位妊娠率、及活产率的差异。结果:观察组与对照组的年龄、病因构成比,反复植入失败周期数,本次解冻周期胚胎移植数目相比较,差异均无统计学意义(P>0.05)。观察组胚胎着床率为27.0%(75/278),对照组为16.4%(41/250),差异有统计学意义(χ2=4.783,P<0.05)。观察组临床妊娠率为50.8%(61/120),对照组为29.2%(35/120),差异有统计学意义(χ2=11.736,P<0.05)。观察组与对照组的流产率、异位妊娠率、双胎及多胎率差异无统计学意义(P>0.05)。观察组活产率为41.7%(50/120),对照组为20.8%(25/120),两组差异有统计学意义(χ2=12.121,P<0.05)。结论:阿托西班可以改善子宫内膜容受性,提高着床率和临床妊娠率,从而改善RIF患者FET的妊娠结局。Objective.. To explore the influence of atoxiban on the pregnancy outcome in patients with repeated implan- tation failure （RIF） in freezing embryo transfer （FET）. Methods： From November 2012 to January 2013, 240 RIF pa- tients in Reproductive Medical Center of Tianjin Obstetric--Gynecologic Hospital who underwent FET were divided in- to two groups, in whom 120 cases used atosiban before FET and 120 cases were as the control. Implantation rate and pregnancy outcome were compared between two groups by SPSS18.0 statistical software. Results： The female age, IVF/ICSI constituent ratio, previous failure cycles and infertile factors of patients did not show statistical differences between the treatment group and the control group （P〈0.05）. The implantation rate of patients in the treatment group increased significantly compared with the control group [27.0%（75/278） vs. 16.4%（41/250）, Z2 =4. 783,P^0. 051. The clinical pregnancy rate increased significantly in the treatment group compared with the control group [50.8 % （61/ 120） vs. 29.2%（35/120）, χ2=11.736,P〈0.05]. The abortion rate, the ectopic pregnancy rate and the multiple pregnancy rate did not show statistical differencse between the treatment group and the control group（P all 〉0.05）. The living--birth rate increased significantly in the treatment group compared with the control group [41.7 %（50/120） vs. 20.8% （25/120）, χ2 =12. 121,P〈0.05]. Conclusion： Atosiban may increase the implantation rate and the preg- nancy rate as well as the endometrial receptivity and the pregnancy outcome.

关 键 词：反售槽人失败 解冻胚胎移植 缩宫素抑制剂 临床妊娠率妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]