Enantioselective synthesis of functionalized fluorinated dihydropyrano[2,3-c]pyrazoles catalyzed by a simple bifunctional diaminocyclohexane-thiourea  

作　　者：Hong-Fei Zhang Zheng-Qing Ye Gang Zhao 

机构地区：[1]Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences

出　　处：《Chinese Chemical Letters》2014年第4期535-540,共6页中国化学快报（英文版）

基　　金：supported by National Basic Research Program of China(973 Program,No.2010CB833200);the National Natural Science Foundation of China(Nos.21032006,203900502,20532040,21290180);Science and Technology Commission of Shanghai Municipality(No.11XD1406400)

摘　　要：Enantioselective synthesis of functionalized fluorinated dihydropyrano[2,3-c]pyrazoles has been achieved via a diaminocyclohexane-thiourea catalyzed cascade Michael addition and Thorpe-Ziegler type cyclization in high yields （up to 98%） with moderate to good enantioselectivity （up to 90% ee）.Enantioselective synthesis of functionalized fluorinated dihydropyrano[2,3-c]pyrazoles has been achieved via a diaminocyclohexane-thiourea catalyzed cascade Michael addition and Thorpe-Ziegler type cyclization in high yields （up to 98%） with moderate to good enantioselectivity （up to 90% ee）.

关 键 词：Trifluoromethyl Pyrazoles Cyclization Organocatalysis 

分 类 号：O626.21[理学—有机化学]