An easy route to exotic 9-epimers of 9-amino-(9-deoxy) cinchona alkaloids with(8S,9R) and(8R,9S)-configurations through two inversions of configuration  

作　　者：Jing-Wei Wan Xue-Bing Ma Rong-Xing He Ming Li 

机构地区：[1]College of Chemistry and Chemical Engineering,Southwest University

出　　处：《Chinese Chemical Letters》2014年第4期557-560,共4页中国化学快报（英文版）

基　　金：Research support from the National Science Foundation ofChina(No.21071116);Chongqing Scientific Foundation,China(No.2010BB4126)

摘　　要：Four exotic chiral organocatalysts, 9-amino-（9-deoxy） cinchona alkaloids with （8S, 9R） and （8R, 9S）- configurations, were conveniently synthesized for the first time in 27-72% total yields through two conversions of configuration at the 9-stereogenic centers of commercially available cinchona alkaloids.Four exotic chiral organocatalysts, 9-amino-（9-deoxy） cinchona alkaloids with （8S, 9R） and （8R, 9S）- configurations, were conveniently synthesized for the first time in 27-72% total yields through two conversions of configuration at the 9-stereogenic centers of commercially available cinchona alkaloids.

关 键 词：Cinchona alkaloids 9-Amino-（9-deoxy） cinchona alkaloids Synthesis Inversion of configuration 

分 类 号：O627.11[理学—有机化学]