A facile electrochemical method for the synthesis of new sulfonamide derivatives of potential biological significance  

作　　者：Davood Nematollahi Saied Saeed Hosseiny Davarani Pari Mirahmadpour Fahimeh Varmaghani 

机构地区：[1]Faculty of Chemistry,Bu-Ali Sina University [2]Department of Chemistry,Faculty of Science,University of Shahid Beheshti [3]Department of Chemistry,Faculty of Science,Arak Branch,Islamic Azad University

出　　处：《Chinese Chemical Letters》2014年第4期593-595,共3页中国化学快报（英文版）

基　　金：Bu-Ali Sina University Research Council and Center of Excellence in Development of Environmentally Friendly Methods for Chemical Synthesis(CEDEFMCS) for their support of this work

摘　　要：The electrochemical synthesis of some new sulfonamide derivatives was carried out via the electrochemical oxidation of 2,3-dihydrophthalazine-l,4-dione （1） in the presence of arylsulfinic acids （2a and 2b） as nucleophiles. The results show that, the electrogenerated phthalazine-l,4-dione （lox） participates in a Michael type addition reaction with 2a or 2b and via an EC mechanism to produce the corresponding sulfonamide derivatives. This method provides a one-pot procedure for the synthesis of new sulfonamide derivatives of potential biological significance in good yields without using toxic reagents at a carbon electrode in an environmentally friendly manner.The electrochemical synthesis of some new sulfonamide derivatives was carried out via the electrochemical oxidation of 2,3-dihydrophthalazine-l,4-dione （1） in the presence of arylsulfinic acids （2a and 2b） as nucleophiles. The results show that, the electrogenerated phthalazine-l,4-dione （lox） participates in a Michael type addition reaction with 2a or 2b and via an EC mechanism to produce the corresponding sulfonamide derivatives. This method provides a one-pot procedure for the synthesis of new sulfonamide derivatives of potential biological significance in good yields without using toxic reagents at a carbon electrode in an environmentally friendly manner.

关 键 词：2 3-Dihydrophthalazine- 1 4-dione Cyclic voltammetry Electrochemical synthesis Sulfonamide Arylsulfinic acid 

分 类 号：TQ460.1[化学工程—制药化工]