Effects of channel blocks on the spiking regularity in clustered neuronal networks  

作　　者：SUN XiaoJuan SHI Xia 

机构地区：[1]School of Science, Beijing University of Posts and Telecommunications

出　　处：《Science China(Technological Sciences)》2014年第5期879-884,共6页中国科学（技术科学英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.11102094;11272065);the Fundamental Research Funds for the Central University of China(Grant No.2013RC0904)

摘　　要：In this paper,we discuss the influences of channel blocks on the spiking regularity in a clustered neuronal network by applying stochastic Hodgkin-Huxley neuronal models as the building blocks.With the aid of simulation results,we reveal that the spiking regularity of the clustered neuronal network could be resonantly enhanced via fine-tuning of the non-blocked potassium channel fraction xK.While the non-blocked sodium channel fraction xNa can enhance the spiking regularity of the clustered neuronal network in most cases.These results indicate that not only sodium channel blocks but also potassium channel blocks could have great influences on the regularity of spike timings in the clustered neuronal networks.Considering the importance of spike timings in neuronal information transforming processes,our results may give some implications for understanding the nonnegligible role of randomness in ion channels in neuronal systems.

关 键 词：channel blocks spiking regularity clustered neuronal networks 

分 类 号：Q42[生物学—神经生物学]