白介素-17、-23在结核性脑膜炎中的免疫致病机制探讨  

The Pathological Mechanism of Interleukin-17,-23 in Tubercular Meningitis Patients

作　　者：程碧珍[1] 杨礼[1] 林诗扬[2] 张俏忻[1] 蔡应木[1] 

机构地区：[1]汕头大学医学院第一附属医院检验科,广东汕头515041 [2]广州医科大学临床医学系

出　　处：《汕头大学医学院学报》2014年第1期33-34,37,共3页Journal of Shantou University Medical College

基　　金：广东省自然科学基金资助项目(S2012010009081)

摘　　要：目的:探讨白介素(IL)-17、-23在结核性脑膜炎(TBM)中的致病机制及其对TBM诊断和预后的意义。方法:用双抗体夹心法检测18例TBM患者(TBM组)血清及脑脊液(CSF)中IL-17、-23因子水平。并对IL-17、-23与TBM组CSF中各参数的相关性进行分析。结果:TBM组血清和CSF中IL-17水平分别为83.8±5.9和106.4±8.8;IL-23水平分别为103.1±7.1和172.8±8.3,与对照组比均有统计学意义(P<0.01)。且IL-17、-23升高水平与TBM组CSF中的WBC数量正相关。结论:IL-17、-23在TBM的免疫致病机制中起着重要作用。Objective：To reveal the pathological mechanism and the prognostic value of interleukin-17,-23 in the tubercular meningitis（TBM）patients. Methods：Serum and CSF of 18 TBM patients were collected to detect IL-17,-23 with ELISA method. The relationship of IL-17,-23 changes with the parameters of CSF was analyzed by the pearson correlation. Results：IL-17,-23 levels in serum and CSF in the TBM group were 83.8±5.9 and 106.4±8.8,103.1±7.1 and 172.8±8.3, respectively. IL-17,-23 in the TBM group were higher than those the control group（P0.01）. IL-17,-23 had correlation with WBC numbers. Conclusion：IL-17,-23 may play important roles in pathological mechanism of TBM.

关 键 词：结核性脑膜炎 白介素-17 白介素-23 

分 类 号：R446.62[医药卫生—诊断学]