原发性高血压患者MAU和颈动脉内膜厚度的相关性  

Correlation of MAU with carotid artery intimamedia thickness in patients with hypertension

作　　者：向勇[1,2] 朱建萍[1,2] 张林[1,2] 

机构地区：[1]湖北医药学院附属人民医院 [2]十堰市人民医院老年病科,湖北十堰442000

出　　处：《中国热带医学》2014年第3期328-330,共3页China Tropical Medicine

摘　　要：目的探讨原发性高血压患者微量白蛋白尿(Microalbuminuria,MAU)与颈动脉内膜厚度的相关性。方法对146例原发性高血压患者分为MAU组42例和非白蛋白尿(NAU)组104例,并以健康体检者50例为对照,比较各组血压、IMT、MAU、TG、LDL-c,并对高血压患者进行MAU与其他指标的Pearson相关和Logistic回归分析。结果 MAU组血压、IMT、TG、LDL-c和MAU高于NAU组和对照组,差异有统计学意义(P均<0.05),NAU组TG和对照组相比差异具有统计学意义(P<0.05);高血压患者IMT、SPB和TG与MAU具有相关性(r=0.486,03115,0.339,P<0.05);对Pearson有意义指标进行逐步Logistic回归分析,仅IMT为MAU的独立影响因子。结论原发性高血压患者MAU和IMT密切相关,可作为高血压的诊断和预后影响因子。Objective To investigate the correlation of MAU with carotid artery intimamedia thickness in patients with hypertension. Methods The 146 primary hypertension patients were divided into two groups （Group MAU, 42 cases; Group NAU, 104 cases）, and 50 cases of healthy people as controls. Blood pressure, IMT, MAU, TG and LDL-c in both groups were compared and analyzed.The Pearson correlation and logistic regression analysis were made between MAU and other indicators in hypertension patients.Results In MAU group, blood pressure, IMT, TG, LDL-c and MAU were higher than that of NAU group and the control group, the difference was statistically significant （P〈0.05）, TG in NAU group compared with the control group, the difference was statistically significant （P〈0.05）. Pearson correlation analysis of MAU in patients with hypertension and other indexes found that IMT, SPB and TG were associated with MAU （r=0.48603115,0.339, P〈0.05）;meaningful indicators were analyzed by logistic regression, only IMT remained in the model as the independent influencing factor of MAU. Conclusion The patients with essential hypertension is closely related to the concetrations of MAU and IMT which can be used as diagnostic and prognostic factors of hypertension.

关 键 词：高血压 微量白蛋白尿 颈动脉内膜厚度 相关性 

分 类 号：R544.11[医药卫生—心血管疾病]