模拟海岛湿热环境条件下猪脊髓火器伤早期血液流变学的变化  

Changes in hemorheology at initial stage following spinal cord firearm injury in the simulated island environment of high temperature and humidity

作　　者：郭瑛 刘来生 贾连顺[2] 云雄 黄智 

机构地区：[1]解放军第一八七中心医院骨一科,海口571159 [2]第二军医大学附属长征医院脊柱外科

出　　处：《中华航海医学与高气压医学杂志》2014年第1期34-37,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：全军十一五指令性课题（08Z018）

摘　　要：目的 分析研究海岛湿热环境下脊髓火器伤后6h内血液流变学的变化特点.方法 18头南方实验用猪按数字表法随机分成常温常湿火器伤组、高温高湿对照组及高温高湿火器伤组,每组6只.构建胸腰段脊髓火器伤动物模型,处理前及处理后0.5、1、2、4、6h分别抽血进行血液黏度、红细胞沉降率、红细胞聚集指数以及变形指数等血液流变学指标检测.结果 高温高湿对照组和常温常湿火器伤组血浆黏度变化差异无统计学意义,但高温高湿火器伤组全血高、中、低切黏度在伤后各时间点与其他2组同一时间点相比差异均存在统计学意义（P ＜0.05或P＜0.01）.3组在处理后血沉均明显高于干预前,但高温高湿火器伤组的血沉值升高尤其明显,6h时明显高于其他2组,差异有统计学意义（P＜0.05）.3组处理后红细胞聚集指数和变性指数的变化趋势各不相同：常温火器伤组在处理后2个指数逐渐升高,高温高湿对照组在处理后先降低后逐渐恢复正常,高温高湿火器伤组处理后先升高,在伤后4～6h急剧降低且低于处理前水平,差异有统计学意义（P＜0.01）.结论 海岛高温高湿环境下脊髓火器伤早期血液流变学变化显著,其变化幅度和趋势与常温常湿火器伤和单纯高温高湿的环境影响均不同,应对这一特殊现象进一步研究,以采取相应的针对性救治措施.Objective To study and analyze changes in hemorheology 6 hours after spinal cord firearm injury in the environment of high temperature and humidity.Methods Eighteen healthy experimental hogs were randomly divided into the normal temperature and humidity firearm injury group,the high temperature and humidity control group and the high temperature and humidity firearm injury group,each consisting of 6 animals.An animal model of firearm spinal cord injury in the thoracic and lumbar section was developed with gunshots.Blood samples were taken to measure such hemorheological indices as blood viscosity,erythrocyte sedimentation,hemagglutination,erythrodegeneration both before intervention and at hours 0.5,1,2,4 and 6 after intervention.Results No statistical significance could be noted in changes of hemorheology for both the high temperature and humidity control group and the normal temperature and humidity firearm injury group,following injury.However,for the high temperature and humidity firearm injury group,statistical differences could obviously be noticed in high-shear,medium-shear and low-shear viscosity in whole blood at various time points after injury,as compared with the data detected at various time points in the other two groups （P ＜ 0.05 or P ＜ 0.01）.Blood sedimentation after intervention was significantly higher than that before intervention.The blood sedimentation level of the high temperature and humidity firearm injury group elevated most significantly,and at hour 6 it was obviously higher than those of the two other groups,with statistical significance.Trend in the changes of red blood cell aggregation and denaturation differed from one another for the 3 groups after intervention.Namely,the above two indices for the normal temperature and humidity firearm injury group increased gradually after intervention,but for the high temperature and humidity control group,the indices soon returned to normal level after they reduced temporarily.As for the high temperature and humidity firearm injury group

关 键 词：高温高湿 脊髓火器伤 血液流变学 

分 类 号：R826.5[医药卫生—临床医学]