星点设计-效应面法优选黄连的提取工艺  

Optimization of Extraction from Coptidis Rhizoma by Central Composite Design and Response Surface Method

作　　者：赵文龙[1] 周昌妮 王佳乐[1] 欧丽婷[1] 贾永艳[1] 

机构地区：[1]河南中医学院药学院,河南郑州450046

出　　处：《中国现代中药》2014年第4期312-315,共4页Modern Chinese Medicine

基　　金：河南中医学院创新性学习项目(yxcx2012-1)

摘　　要：目的:优选黄连的提取工艺。方法:以总生物碱的含量为指标,采用星点设计-效应面法对乙醇体积分数、乙醇用量、提取时间进行考察。结果:最优提取工艺为12倍量含80﹪乙醇回流提取3次,每次0.5 h。结论:优化后的工艺稳定可行,可用于黄连的提取。Objective： To optimize the extraction process of Coptidis Rhizoma. Methods： Using central composite design and response surface method to investigate the Fufang Gehuang osmotic pump tablet extraction with ethanol concentration, dosage of ethanol, extraction time. Results： The optimal extraction process of Fufang Gehuang osmotic pump tablet is： 12 times the amount of 80% ethanol, extracted three times, each time for 0. 5 hours. Conclusion： The optimized process is stable and feasible, and can be used for extracting Fufang Gehuang osmotic pump tablet.

关 键 词：黄连 星点设计 总生物碱 工艺优选 

分 类 号：R971[医药卫生—药品]