武汉市儿童手足口病病原学研究  

Etiological analysis of hand-foot-mouth disease in Wuhan

作　　者：吴志强[1] 熊焰[1] 项杰[1] 周虹[1] 伍仕敏[1] 

机构地区：[1]武汉市医疗救治中心,武汉430023

出　　处：《临床血液学杂志（输血与检验）》2014年第2期303-304,共2页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:了解武汉市2012年手足口病的病原学情况,为本地区手足口病的防治提供依据。方法:用实时荧光定量RT-PCR方法检测患者咽拭子中肠道病毒71型(EV71)和柯萨奇病毒A组16型(CA16)核酸。结果:332例患者中,EV71核酸阳性110例,阳性率33.1%;其中83例患者进行了CA16检测,阳性率20.5%;EV71和CA16双阳性2例,阳性率2.4%;手足口病男性患儿人数明显高于女性(P<0.05)。结论:武汉市儿童手足口病主要是感染EV71,同时伴有CA16的流行。Objective： To understand the characteristics of etiology of hand-foot-mouth disease （HFMD） in Wuhan, and provide laboratory data for the epidemic control and patient care. Method： Throat swab samples were collected from 332 HFMD cases, and EV71 and CA16 were detected by Real-time PCR. Result： Among 332 HFMD samples, 33.1% were infected by EV71; 83 patients were detected with CA16, the positive rate of CA16 was 20. 5% ; 2.4% were cases infected by both. The number of boys was larger than that of girls （P〈0.05）. Conclusion：Children with HFMD infected mainly EV71, prevailing CA16 at the same time.

关 键 词：手足口病 肠道病毒71型 柯萨奇病毒A组16型 实时荧光定量RT-PCR 

分 类 号：R373.2[医药卫生—病原生物学]