江西汉族人HLA-B*1502与卡马西平所致SJS/TEN相关性分析  

Association between HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Hanzu people in Jiangxi province

作　　者：刘藕根[1] 邹叶青[2] 李春明[1] 刘志刚[1] 

机构地区：[1]南昌大学第二附属医院皮肤科,江西南昌330006 [2]南昌大学第二附属医院分子中心,江西南昌330006

出　　处：《临床皮肤科杂志》2014年第5期272-274,共3页Journal of Clinical Dermatology

基　　金：江西省卫生厅普通科技计划(20121078)资助项目

摘　　要：目的：探讨具有江西汉族遗传背景人群中人类白细胞抗原（HLA）-B＊1502与卡马西平（CBZ）所致Stevens-Johnson综合征／中毒性表皮坏死症（SJS／TEN）相关性。方法：在具有江西汉族遗传背景人群中，收集CBZ所致SJS／TEN患者19例，以及90例服用CBZ无过敏患者和80例健康对照者，采用序列特异性引物聚合酶链反应法进行HLA—B＊1502的基因型测定．观察CBZ所致的SJS／TEN与HLA—B＊1502基因型是否存在关联。结果：CBZ所致SJSfrEN组HLA—B＊1502基因型携带率为100％，显著高于CBZ耐受组（15．5％）及健康对照组（18．75％），差异均具有统计学意义（P〈0．001）。CBZ耐受组HLA—B＊1502基因型携带率与健康对照组比较，差异无统计学意义（生0．684）。结论：具有江西汉族遗传背景人群中．HIJA—B＊1502与CBZ所致SJSfrEN有极强的相关性。Objective： To determine whether HLA-B＊1502 allele is associated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal neerolysis in Hanzu people in Jiangxi province. Methods： HLA-B＊1502 allele genotyping was performed by a polymerase chain reaction-sequence specific primers （PCR-SSP） method in 19 Han subjects who had carba- mazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis, 90 carbamazepine tolerant controls,and 80 healthy individuals. Results： The frequency of HLA-B＊1502 allele in SJS/TEN patients was significantly higher than that in carba- mazepine-tolerant controls（100% vs.15.5%, P〈0.001） and normal individuals （100% vs.18.75%, P〈0.001）. But the frequency in carbamazepine-tolerant controls did not differ significantly from that in healthy controls （P=-0.684）. Conclusions： There is a strong association between HLA-B＊1502 allele and carbamazepine-induced Stevens-Johnson syndrome, and toxic epidermal neerolysis in Hanzu people in Jiangxi province.

关 键 词：人类白细胞抗原HLA—B＊1502 卡马西平 Stevens—Johnson综合征 中毒性表皮坏死症 汉族 江西省 

分 类 号：R751[医药卫生—皮肤病学与性病学]