替加环素联合用药的研究进展  

Research progress of tigecycline in combination with other drugs

作　　者：吴永杰[1] 白艳[2] 王睿[3] 陈鲲[4] 王瑾[3] 黄晓舞[1] 

机构地区：[1]中国人民解放军总医院医疗物资采购中心,北京100853 [2]中国人民解放军总医院药品保障中心,北京100853 [3]中国人民解放军总医院药物临床研究中心,北京100853 [4]大理学院药学与化学学院,云南大理671000

出　　处：《中国新药与临床杂志》2014年第4期237-241,共5页Chinese Journal of New Drugs and Clinical Remedies

基　　金：十二五国家重大科技专项(2012ZX09303004-002)

摘　　要：替加环素与其他抗菌药物联合使用已经成为抗感染领域研究的热点之一,近年来在体外实验、动物模型、病例报道、临床应用等研究中有相关报道。例如:体外实验研究中,替加环素与其他药物如利福平、阿米卡星、多黏菌素等联用时,表现出协同作用;动物实验研究结果也显示,替加环素与多黏菌素合用可以治疗肺炎克雷伯菌感染引起的菌血症和绿脓杆菌感染引起的骨髓炎等。本文通过查阅近年来替加环素联合用药的国内外相关文献,对其研究进展进行综述,以便更好地了解替加环素联合用药情况,为临床合理用药提供理论基础。The combination use of tigecycline with other antimicrobial agents has become one of the hot spots in the field of anti-infective research in recent years. In vitro experiments, animal models, case reports, and clinical applications have been reported in the past few years. For example, tigecycline in combination with other drugs such as rifampin, amikacin and colistin in vitro has been reported the effect of synergy; animal experiments studies reported tigecycline combined with colistin can treat bacteremia caused by Klebsiella pneumoniae and osteomyelitis caused by Pseudomonas aeruginosa, etc. This paper summarized the progress of tigecycline combination therapy with other drugs by consulting relevant literatures at home and abroad in recent years, in order to better understand this combination use and to provide some theoretical basis for the further research of tigecycline in clinical rational drug combination.

关 键 词：替加环素 抗菌药 药物疗法 联合 

分 类 号：R978.1[医药卫生—药品]