重度颅脑创伤后认知功能障碍患者蒙特利尔认知评估量表评分与扩散张量成像的相关性研究  

Diffusion tensor imaging and the Montreal cognitive assessment for assessing severe traumatic brain injury

作　　者：张小年[1] 侯亚静[2] 孙新亭[1] 迟茜茜[1] 张皓[1] 

机构地区：[1]中国康复研究中心北京博爱医院,首都医科大学康复医学院,北京100068 [2]首都医科大学附属复兴医院

出　　处：《中华物理医学与康复杂志》2014年第4期266-269,共4页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的研究重度颅脑创伤（TBI）后认知障碍患者蒙特利尔认知评估量表（MoCA）评分与扩散张量成像（DTI）的相关性。方法选择重度TBI恢复期男性患者8例作为研究对象，所有患者均采用MoCA评分评定其记忆、注意、语言、执行等各项功能，同时采用DTI测量感兴趣区（放射冠、上纵束、下纵束、内囊、胼胝体膝部、胼胝体体部、胼胝体压部和扣带回）白质纤维束的各异向性（FA）值，最后采用Pearson软件分析MoCA评分与感兴趣区FA值的相关性。结果胼胝体体部、胼胝体膝部和上纵束的FA值与MoCA评分均具有相关性，r值分别为r=0．746，P〈0．05；r=0．689，P〈0．05；r=0．748，P〈0．05。结论重度颅脑创伤患者的胼胝体体部、胼胝体膝部、上纵束白质纤维束损伤与认知障碍显著的相关性。Objective To investigate any correlation between diffusion tensor imaging （DTI） results and Montreal cognitive assessment （MoCA） scores after severe traumatic brain injury （TBI）. Methods Eight male pa- tients with chronic severe TBI were given the MoCA （including memory, attention, speech and executive function）. DTI was used to quantify the fractional anisotropy （FA） of white matter fiber tracts in the radial and longitudinal fas- ciculus, under longitudinal fasciculus, internal capsule, corpus callosum genu and body, and the cingulate cortex. Pearson correlation coefficients were calculated to quantify the correlation between the FA values and MoCA scores. Results There was a positive correlation between FA in the corpus callosum body, corpus callosum genu and the su- perior longitudinal fasciculus and MoCA total scores. Conclusion The MoCA scores of patients with chronic se- vere TBI are related to white matter damage in the corpus callosum body, corpus callosum genu and the superior lon- gitudinal fasciculus.

关 键 词：颅脑创伤 认知障碍 蒙特利尔认知评估量表 扩散张量成像 康复 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]