Spontaneous brain activity in chronic smokers revealed by fractional amplitude of low frequency fluctuation analysis： a resting state functional magnetic resonance imaging study  

作　　者：Chu Shuilian Xiao Dan Wang Shuangkun Peng Peng Xie Teng He Yong Wang Chen 

机构地区：[1]Beijing Chao Yang Hospital, Capital Medical University, Beijing 100020, China [2]World Health Organization Collaborating Centre for Tobacco and Health, Beijing Institute of Respiratory Medicine, Beijing 100020, China [3]Department of Respiratory Medicine, Capital Medical University, Beijing 100069, China

出　　处：《Chinese Medical Journal》2014年第8期1504-1509,共6页中华医学杂志（英文版）

基　　金：This study was supported by grants fromthe National Nature Science Foundation of China （No. 81200066） and National Science and Technology Support Program （No. 2012BAI05B02）.

摘　　要：Background Nicotine is primarily rsponsible for the highly addictive properties of cigarettes. Similar to other substances, nicotine dependence is related to many important brain regions, particular in mesolimbic reward circuit. This study was to further reveal the alteration of brain function activity dudng resting state in chronic smokers by fractional amplitude of low frequency fluctuation （fALFF） based on functional magnetic resonance imaging （fMRI）, in order to provide the evidence of neurobiological mechanism of smoking. Methods This case control study involved twenty healthy smokers and nineteen healthy nonsmokers recruited by advertisement. Sociodemographic, smoking related characteristics and fMRI images were collected and the data analyzed. Results Compared with nonsmokers, smokers showed fALFF increased significantly in the left middle occipital gyrus, left limbic lobe and left cerebellum posterior lobe but decreases in the right middle frontal gyrus, right superior temporal gyrus, right extra nuclear, left postcentral gyrus and left cerebellum anterior lobe （cluster size 〉100 voxels）. Compared with light smokers （pack years 〈20）, heavy smokers （pack years 〉20） showed fALFF increased significantly in the right superior temporal gyrus, right precentral gyrus, and right occipital Iobe/cuneus but decreased in the right/left limbic Iobe/cingulate gyrus, right/left frontal lobe/sub gyral, right/left cerebellum posterior lobe （cluster size 〉50 voxels）. Compared with nonsevere nicotine dependent smokers （FagerstrSm test for nicotine dependence, score 〈6）, severe nicotine dependent smokers （score 〉6） showed fALFF increased significantly in the right/left middle frontal gyrus, right superior frontal gyrus and left inferior parietal Iobule but decreased in the left limbic Iobe/cingulate gyrus （cluster size 〉25 voxels）. Conclusions In smokers during rest, the activity of addiction related regions were increased and the activity of smoking feeling, memory, related Background Nicotine is primarily rsponsible for the highly addictive properties of cigarettes. Similar to other substances, nicotine dependence is related to many important brain regions, particular in mesolimbic reward circuit. This study was to further reveal the alteration of brain function activity dudng resting state in chronic smokers by fractional amplitude of low frequency fluctuation （fALFF） based on functional magnetic resonance imaging （fMRI）, in order to provide the evidence of neurobiological mechanism of smoking. Methods This case control study involved twenty healthy smokers and nineteen healthy nonsmokers recruited by advertisement. Sociodemographic, smoking related characteristics and fMRI images were collected and the data analyzed. Results Compared with nonsmokers, smokers showed fALFF increased significantly in the left middle occipital gyrus, left limbic lobe and left cerebellum posterior lobe but decreases in the right middle frontal gyrus, right superior temporal gyrus, right extra nuclear, left postcentral gyrus and left cerebellum anterior lobe （cluster size 〉100 voxels）. Compared with light smokers （pack years 〈20）, heavy smokers （pack years 〉20） showed fALFF increased significantly in the right superior temporal gyrus, right precentral gyrus, and right occipital Iobe/cuneus but decreased in the right/left limbic Iobe/cingulate gyrus, right/left frontal lobe/sub gyral, right/left cerebellum posterior lobe （cluster size 〉50 voxels）. Compared with nonsevere nicotine dependent smokers （FagerstrSm test for nicotine dependence, score 〈6）, severe nicotine dependent smokers （score 〉6） showed fALFF increased significantly in the right/left middle frontal gyrus, right superior frontal gyrus and left inferior parietal Iobule but decreased in the left limbic Iobe/cingulate gyrus （cluster size 〉25 voxels）. Conclusions In smokers during rest, the activity of addiction related regions were increased and the activity of smoking feeling, memory, related

关 键 词：SMOKING magnetic resonance imaging brain 

分 类 号：R445.2[医药卫生—影像医学与核医学]