血管性疾病患者心踝血管指数与血浆同型半胱氨酸水平的相关性研究  

Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases

作　　者：王宏宇[1] 刘金波[1] 王琦[1] 赵红薇[1] 史鸿燕[1] 于晓岚[1] 付晓葆[1] 

机构地区：[1]北京大学首钢医院血管医学中心,北京100144

出　　处：《英国医学杂志中文版》2014年第2期90-94,共5页The BMJ Chinese Edition

摘　　要：目的心踝血管指数（CAVI）是新的评价动脉僵硬度的指标，其不依赖于测量时的即刻血压水平。同型半胱氨酸（Hey）是血管性疾病的独立危险因子。本研究主要探讨血管性疾病患者中CAVI与Hey之间的相关性。设计描述性研究。人群入选伴或不伴有高血压、冠心病、下肢动脉闭塞症患者88例（男／女为46／42），人选人群根据Hey水平分为对照组及高同型半胱氨酸血症（HHcy，Hey≥15μmol／L）组。方法CAVI、颈一股脉搏波传导速度（CF—PwV）及颈．桡脉搏波传导速度（CR—PWV）由动脉僵硬度自动检测装置Vs-1000及Complior测定。结果整体人群中，血浆Hcy与cF-PwV、CR—PwV、CAVI呈显著正相关性（依次分别为r=0．33，P=0．002；r=0．51，P〈0．001；r=0．42，P〈0．001）。血管性疾病人群中，血浆Hey与cF—PwV、CR—PwV、CAVI呈显著正相关性（r=0．23，P：0．048；r=0．51，P〈0．001；r=0．392，P=0．001）。伴有一种或多种血管性疾病人群血浆Hey水平显著高于不伴有血管性疾病人群组。Hey≥15μmol／L组CF．PwV、CR—PwV、CAVI水平显著高于Hey〈15μmol／L组人群。多元线性回归分析提示整体人群中Hey、体质指数、年龄是CAVI的独立相关因素（p=0．421，P=0．001；B=-0．309，P=0．006；B=0．297，P=0．012），而血管性疾病人群中，Hcy、体质指数、年龄是CAVI的独立相关因素（B=0．434，P=0．001；B=-0．331，P：0．009；p=0．288，P=0．022）。结论血管性疾病患者中CAVI与血浆Hey呈显著正相关性。Objectives Cardioankle vascular index （CAVI） is a newindex of arterial stiffness independent of immediate blood pressure. Homocysteine （Hcy） is an independent risk factor for vascular diseases. The aim of this study was to investigate the relationship between Hey and CAVI in the vascular-related diseases. Design Descriptive research. Participants 88 patients （ M/F 46/42 ） with or without hypertension, coronary artery disease or arteriosclerosis obliterans were enrolled to our study. They were divided into two groups according to the level of Hcy. Methods CAVI, carotid-femoral pulse wave velocity （CFPWV） and carotid-radial pulse wave velocity （CR-PWV） were measured by VS-1000 and Complior apparatus. Results There was significant correlation between Hcy and CF-PWV, CR-PWV, CAVI in the entire group （r = 0. 33, P= 0.002; r = 0.51, P 〈 0.001; r = 0.42, P 〈 0.001, respectively）. And there was significant correlation between Hcy and CF-PWV, CR-PWV, CAVI in the vascular-related disease group （r=0.23, P=0.048; r =0.51, P〈0.001; r =0.392, P = 0. 001, respectively）. The level of Hcy was significantly higher in patients with one or more vascular diseases than in patients without vascular diseases. The levels of CF-PWV, CR- PWV and CAVI were significantly higher in Hcy ≥ 15 μmol/L group than in Hcy〈5 μmol/L group （13.7 ±3.0 vs 10.8 ± 2.5, P〈 0.001; 10.6±2.1 vs9.2±1.6, P=0.001;9.30± 2.1 vs 7.79 ± 2. 1, P = 0. 001, respectively ）. Multiple linear regression showed that Hey, body mass index （BMI） and age were independent associating factors of CAVI in the entire study group （β=0.421, P=0.001;β= -0.309, P=0.006;β= 0. 297, P = 0. 012, respectively）. And Hey, BMI and age were independent influencing factors of CAVI in the vascular - relateddisease group （β=0.434, P =0.001; β = -0.331, P = 0. 009;β =0. 288, P =0. 022, respectively）. Conclusions CAVI was positively correlated with Hey in the vascular-related diseases.

关 键 词：血浆同型半胱氨酸 血管性疾病 血管指数 血压水平 相关性 患者 脉搏波传导速度 高同型半胱氨酸血症 

分 类 号：R587.1[医药卫生—内分泌]