神经妥乐平联合鼠神经生长因子对腰椎间盘突出症术后神经症状的影响  

Effects of neurotropin combined with mouse nerve growth factors on neurological symptoms after the operation of lumbar disc herniation

作　　者：车武[1] 全洪波[2] 袁唯[1] 曹露[1] 李熙雷[1] 姜允琦[1] 周晓岗[1] 董健[1] 

机构地区：[1]复旦大学附属中山医院骨科,上海200032 [2]复旦大学附属中山医院(分部)内科

出　　处：《中国骨与关节杂志》2014年第4期261-264,共4页Chinese Journal of Bone and Joint

基　　金：上海市医学重点项目(09411953800);上海市医学重点项目(12411951300);上海市"科技创新行动计划"基础研究领域重点项目(12JC1402600)

摘　　要：目的观察神经妥乐平联合鼠神经生长因子对腰椎间盘突出症术后残留下肢神经症状的治疗作用。方法选择2011年5月至2013年5月于本院骨科就诊的患者,按入组标准共有47例腰椎间盘突出症术后残留神经症状的患者(术后4周,VAS≥50分)入组。分为联合用药组25例和对照组22例。联合用药组使用鼠神经生长因子联合神经妥乐平,对照组则仅用鼠神经生长因子。两组均在治疗前后分别记录症状及体征,采用视觉模拟评分法(visual analogue scale,VAS)及功能障碍指数(oswestry disability index,ODI)评分进行评定,并按治疗后症状改善情况计算总有效率。结果治疗14天与治疗3个月时两组间的VAS及ODI评分差异有统计学意义(P<0.05)。治疗14天时两组的总有效率在64.0%和45.5%,(P<0.05)差异有统计学意义;治疗3个月时两组的总有效率在72%和50%,(P<0.05)差异有统计学意义。结论联合应用神经妥乐平和鼠神经生长因子对腰椎间盘突出症术后残留下肢神经症状有较好的缓解作用。Objective To observe the therapeutic effects of neurotropin combined with mouse nerve growth factors for residual neurological symptoms in the lower extremities after the operation of lumbar disc herniation. Methods From May 2011 to May 2013, 47 patients with residual neurological symptoms at 4 weeks after the operation of lumbar disc herniation were studied according to the inclusion criteria, and their Visual Analogue Scale （ VAS ） scores were more than 50 points. The total effective rate was obtained according to the improved symptoms after the treatment. All the patients were divided into 2 groups, including the combination group （ n=25 ） and the control group （ n=22 ）. In the combination group, mouse nerve growth factors combined with neurotropin were used, while in the control group only mouse nerve growth factors were used. The symptoms and signs in both groups were respectively recorded before and after the treatment, and the VAS and Oswestry Disability Index （ ODI ） were used in the evaluation. Results The differences in the VAS and ODI scores between the 2 groups were statistically signiifcant at the 14th day and 3rd month after the start of the treatment （ P＆lt;0.05 ）. The total effective rates of the 2 groups were 64.0%and 45.5%respectively at the 14th day after the start of the treatment, and the differences were statistically signiifcant （ P＆lt;0.05 ）. The total effective rates were 72%and 50%respectively at the 3rd month after the treatment, and the differences were statistically signiifcant （ P＆lt;0.05 ）. Conclusions The mitigative effect is better under the combined application of neurotropin and mouse nerve growth factors in the treatment of residual neurological symptoms in the lower extremities after the operation of lumbar disc herniation. {URL}： http：//d.g.wanfangdata.com.cn/Periodical_zggzlzz201404007.aspx

关 键 词：神经生长因子 椎间盘移位 腰椎 治疗结果 神经妥乐平 

分 类 号：R687.3[医药卫生—骨科学]