左侧壳核软化灶致右侧肢体疼痛:人脑边缘区静息态功能磁共振成像  

Right Extremities Pain Caused by A Malacia Lesion in the Left Putamen:A Resting Functional Magnetic Resonance Imaging of the Marginal Division of the Human Brain

作　　者：陈志晔[1] 马林[1] 

机构地区：[1]中国人民解放军总医院放射科,北京100853

出　　处：《中国医学科学院学报》2014年第2期126-130,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81371514);解放军总医院苗圃基金(13KMM41)~~

摘　　要：目的采用静息态脑功能成像研究边缘区在疼痛中的作用机制。方法对1例左侧壳核软化灶导致右侧躯体偏身疼痛患者及8名健康志愿者进行静息态脑功能成像研究,手工勾画边缘区蒙片,进行全脑基于感兴趣区的功能连接计算。结果左侧边缘区功能连接较健康对照显著下降,主要位于双侧尾状核头、壳核及左侧苍白球。结论边缘区可能参与人类疼痛调节,机制尚有待于进一步研究。Objective To explore the role of marginal division of the human brain in the pain modulafunctional magnetic resonance imaging was applied in a patient with right extremities pain caused by a malacia lesion in the left putamen and in 8 healthy volunteers. Marginal division was defined using manual drawing on structure images, and was applied to the computation of fuctional connectivity maps. Results The functional connectivities in the left marginal division showed an evident decrease in the patient when cornpared with healthy controls. These connectivities were mainly located in the bilateral head of caudate nucleus, putamen, and left globus pallidus. Conclusion The marginal division may be involved in the pain modulation.

关 键 词：边缘区 壳核 脑 功能磁共振成像 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学]